高尿酸血症对特发性膜性肾病临床及病理的影响  

Clinical and pathological influence of high uric acid on idiopathic membranous nephropathy

作　　者：黄爱芳[1] 王娟[1] 彭茜[1] 黎伟[1] 

机构地区：[1]广西医科大学第一附属医院肾内科,南宁市530021

出　　处：《实用医学杂志》2017年第8期1227-1230,共4页The Journal of Practical Medicine

基　　金：广西科技计划项目(编号:桂科AB16380228);广西中医药民族医药科研项目(编号:GZZC14-54)

摘　　要：目的:探讨高尿酸血症对特发性膜性肾病(IMN)的临床及病理的影响。方法:回顾分析2014年1月至2016年6月在广西医科大学第一附属医院肾内科确诊为IMN的314例患者临床及病理特征,并分析高尿酸血症对IMN临床及病理的影响。结果:(1)314例IMN患者高尿酸血症发病率为23.2%(73例);(2)IMN伴高尿酸血症患者的年龄、病程、血压和症状等临床资料与正常尿酸IMN患者间的差异有统计学意义(P<0.05);(3)IMN伴高尿酸血症患者血脂和肾功能等实验室指标较正常尿酸水平IMN患者间差异有显著性(P<0.05);(4)IMN伴高尿酸血症患者的病理损伤较正常尿酸水平IMN肾病患者严重,差异有统计学意义(P<0.05)。结论:高尿酸血症可能加重IMN临床及病理损伤,临床应重视尿酸对IMN的影响,采取综合有效的治疗措施,延缓疾病的发展。Objective To Study the clinical and pathological influence of high uric acid on idiopathic membranous nephropathy （IMN） Methods A retrospective study with 314 patients diagnosed with IMN from January 2014 to June 2016 was conducted and the clinical pathological influence of high uric acid on IMN was analyzed. Results （ 1 ） Of the total, the prevalence of hyperuricaemia patients was 23.2% （73 cases） ; （2） The difference of age, course of the disease, blood pressure and symptoms between hyperuricaemia IMN patients and IMN patients with normal uric acid was statistically significant （P 〈 0.05） ; （3） Laboratory test indexes such as blood lipid and renal function between hyperuricaemia IMN patients and IMN patients with normal uric acid indicated statistical significance （P 〈 0.05 ） ; （4） The pathological damage was aggravated in hyperuricaemia IMN patients （P 〈 0.05）. Conclusion High uric acid can enhance the clinical and pathological damage of IMN, and comprehensive and effective treatments should be conducted to delay the development of disease.

关 键 词：高尿酸 膜性肾病 临床及病理 

分 类 号：R589.7[医药卫生—内分泌] R692[医药卫生—内科学]