川崎病患儿血清YKL-40的变化及与冠状动脉病变之间的关系  

Relationship between serum YKL-40 and coronary artery lesions in children with Kawasaki disease

作　　者：孙东明[1] 许渝[2] 张丽萍[1] 张勇[1] 刘玲[1] 夏琨[1] 彭静[1] 王丹丹[1] 

机构地区：[1]武汉市妇女儿童医疗保健中心心内科,武汉430016 [2]武汉市妇女儿童医疗保健中心医院感染科

出　　处：《临床心血管病杂志》2017年第4期328-330,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨YKL-40在川崎病(KD)发病中的作用,及其与KD冠状动脉病变(CAL)之间的关系。方法:收集2015-06-2016-06在武汉市妇女儿童医疗保健中心住院的KD患儿86例,将其分为KD无CAL组72例、KD伴CAL组14例,并随机选取同期住院的上呼吸道感染并发热患儿40例作为对照组,比较各组血清YKL-40、白细胞(WBC)、血小板(PLT)、C反应蛋白(CRP)、红细胞沉降率(ESR)、纤维蛋白原(FIB)水平的差异。结果:KD无CAL组YKL-40、WBC、PLT、CRP、ESR、FIB水平均较对照组明显升高,差异有统计学意义(P<0.01)。KD伴CAL组血清YKL-40水平较KD无CAL组明显升高,差异有统计学意义(P<0.01),而两组WBC、PLT、CRP、ESR、FIB水平无显著性差异(P>0.05)。结论:YKL-40可能参与了KD的发病,可作为KD冠状动脉损伤的一种新的预测指标。Objective：To investigate the role of YKL-40 in the pathogenesis of Kawasaki disease（KD）and its relationship with coronary artery lesions（CAL）.Method：The 86 children with KD were enrolled and divided into two groups：72cases of KD without CAL and 14 cases of KD with CAL.Another 40 children with upper respiratory tract infection and fever who were hospitalized during the same period were randomly selected as the control group.Then we compared the levels of serum YKL-40,white blood cell（WBC）,platelet（PLT）,C-reactive protein（CRP）,erythrocyte sedimentation rate（ESR）,fibrinogen（FIB）in three groups.Result：the levels of YKL-40,WBC,PLT,CRP,ESR and FIB in the KD group without CAL were significantly higher than those in the control group,and the differences were statistically significant（P〈0.01）.The serum YKL-40 level of KD group with CAL was significantly higher than that of KD group without CAL,the differences statistically significant（P〈0.01）,while the levels of WBC,PLT,CRP,ESR and FIB were not significantly different between the two groups（P〈0.05）.Conclusion：YKL-40 plays an important role in the pathogenesis of KD and is used as a new predictor of coronary artery lesions in patients with KD.

关 键 词：川崎病 冠状动脉病变 YKL-40 

分 类 号：R541.4[医药卫生—心血管疾病]