~1H-MRS分析对侵袭性垂体腺瘤的诊断价值  

Value of ~1H-magnetic resonance spectroscopy for the diagnosis of invasive pituitary adenoma

作　　者：杨柳[1] 彭燕[1] 刘云[1] 陈佳[1] 龚明福[1] 

机构地区：[1]第三军医大学新桥医院放射科,重庆400037

出　　处：《放射学实践》2017年第4期369-372,共4页Radiologic Practice

基　　金：国家自然科学基金(81501521)

摘　　要：目的:探讨~1H-磁共振波谱成像(~1H-MRS)对侵袭性垂体腺瘤的诊断价值。方法:对56例经病理证实的垂体腺瘤患者的~1H-MRS数据进行回顾性分析,其中侵袭性36例、非侵袭性20例。测量和计算两组患者病变区的胆碱(Cho)/肌酸(Cr)、N-乙酰天门冬氨酸(NAA)/Cr、肌醇(MI)/Cr、乳酸脂质(LL)/Cr及Cho/NAA的值,并进行统计学分析。结果:Cho/Cr、LL/Cr、MI/Cr、NAA/Cr及Cho/NAA的值在侵袭性组中分别为3.913±2.091、2.435±1.645、1.466±1.319、1.169±0.781及3.865±1.890,在非侵袭性组中分别为1.796±0.612、3.552±2.716、1.340±1.010、1.069±0.774和1.799±0.581,两组间仅Cho/NAA和Cho/Cr的差异有统计学意义(P<0.05)。受试者工作特征(ROC)曲线分析显示,当Cho/NAA值大于2.045时,诊断侵袭性垂体腺瘤的敏感度为89.9%,特异度为80.0%,符合率为88.5%;当Cho/Cr值大于1.900时,诊断侵袭性垂体腺瘤的敏感度为86.1%,特异度为65.0%,符合率为83.6%。结论:~1H-MRS对侵袭性垂体腺瘤的诊断具有一定参考价值。Objective：To study the value of 1 H-magnetic resonance spectroscopy （1 H-MRS） in the diagnosis of inva- sive pituitary adenoma. Methods..1 H-MRS data of 56 patients with pathology proven pituitary adenoma were retrospectively analyzed,which were divided into invasive group （36 cases） and non-invasive group （20 cases）. Cho/Cr,NAA/Cr,MI/Cr, LL/Cr and Cho/NAA of the lesions were measured and calculated, statistical analyses were performed. Results： The ratio of Cho/Cr,LL/Cr,MI/Cr,NAA/Cr and Cho/NAA in invasive group was 3. 913 ± 2. 091,2. 435 ±1. 645,1. 466±1. 319, 1. 169±0. 781 and 3. 865±1. 890,respectively,in non-invasive group was 1. 796±0. 612,3. 552±2. 716,1. 340±1. 010, 1. 069±0. 774 and 1. 799 ±0. 581, respectively. Only the values of Cho/NAA and Cho/Cr of invasive pituitary adenoma were significantly higher than that of non-invasive pituitary adenoma,with statistical differences （P〈0.05）. Receiver operating characteristic （ROC） curve showed that when Cho/NAA ratio was greater than 2. 045, the diagnosis sensitivity, specificity and accuracy for invasive pituitary adenoma was 89.9%, 80.0% and 88. 5%, respectively. When Cho/Cr ratio was greater than 1. 900 ,the diagnosis sensitivity, specificity and accuracy for invasive pituitary adenoma was 86.1 %, 65.0 %and 83.6 % respectively. Conclusion：1 H-MRS has certain reference value for the diagnosis of invasive pituitary adenoma.

关 键 词：垂体腺瘤 磁共振波谱成像 胆碱 肌酸 N-乙酰天门冬氨酸 

分 类 号：R445.2[医药卫生—影像医学与核医学] R736.4[医药卫生—诊断学]