丹参注射液联合尼莫地平缓释片治疗高血压出血性脑卒中的临床研究  

Clinical trial of Salvia miltiorrhiza injection combined with nimodipine sustained release tablets in the treatment of hypertensive hemorrhagic stroke

作　　者：王爱岳[1] 李强[2] 余丹[1] 周治平[1] WANG Ai - yue LI Qiang YU Dan ZHOU Zhi -ping(Department of Neurology, Haikou City People＇ s Hospital, Haikou 570208, China Department of Neurology, Hainan Province Agricultural Reclamation Administration Hospital, Haikou 570000, China)

机构地区：[1]海口市人民医院神经内科,海口570208 [2]海南省农垦总局医院神经内科,海口570000

出　　处：《中国临床药理学杂志》2017年第8期681-683,共3页The Chinese Journal of Clinical Pharmacology

基　　金：海南省自然科学基金资助项目(30716)

摘　　要：目的观察丹参注射液联合尼莫地平缓释片治疗高血压出血性脑卒中的临床疗效及安全性。方法将106例新发高血压出血性脑卒中患者分为对照组64例和试验组42例。对照组予以吸氧、吸痰、控制脑水肿、维持电解质平衡、营养脑细胞等常规治疗;试验组在对照组治疗的基础上,予以丹参注射液10 mg·d^(-1),静脉滴注速度<1 mg·h^(-1)+尼莫地平缓释片每次20 mg,tid,口服。2组患者均治疗14 d。比较2组患者的临床疗效、血肿吸收情况,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为95.24%(40/42例)和85.94%(55/64例),差异有统计学意义(P<0.05)。治疗后第14,28天,试验组的平均血肿体积分别为(8.26±4.39),(6.76±3.16)mL,对照组的平均血肿体积分别为(12.41±5.02),(9.33±4.78)mL,差异均有统计学意义(均P<0.05)。试验组的药物不良反应主要有头痛、胃肠道反应、低血压、血小板减少、皮肤刺痛,对照组的药物不良反应主要有头痛、胃肠道反应。试验组和对照组的药物不良反应发生率分别为19.04%(8/42例)和7.81%(5/64例),差异无统计学意义(P>0.05)。结论丹参注射液联合尼莫地平缓释片治疗高血压出血性脑卒中的临床疗效肯定,能显著地促进血肿的吸收,且不增加药物不良反应的发生率。Objective To observe the clinical efficacy and safety of Salvia miltiorrhiza injection combined with nimodipine sustained release tablets in the treatment of hypertensive hemorrhagic stroke. Methods The 106 patients with hypertensive hemorrhagic stroke were divided into control group （n = 64 cases ） and treatment group （n = 42 cases ）. Control group was given oxygen, suction, control brain edema, maintain electrolyte balance, nutrition, brain cells and other conventional treatment. Treatment group was given Salvia miltiorrhiza injection 10 mg · d^-1 , the speed of intravenous infusion 〈 1 mg · h^-1 ＋ nimodipine sustained release tablets 20 mg tid oral, on the basis of control group. Two groups were treated for 14 d. The clinical efficacy, hematoma absorption and adverse drug reactions were compared between two groups. Results After treatment, the total effective rates of treatment and control groups were 95.24% （40/42 cases ） and 85.94% （55/64 cases）, with significant difference （ P 〈 0.05 ）. After treatment for 14, 28 d, the mean hematoma volume in treatment group were （8.26±4.39）, （6.76 ±3.16） mL, which in control group were （12.41 ±5.02）, （9.33 ±4.78） mL, with significant difference （ P 〈 0.05 ） . The adverse drug reactions in treatment group were headache, gastrointestinal reaction, hypotension, thrombocytopenia and skin prick, which in control group were headache and gastrointestinal reaction. The incidences of adverse drug reactions in treatment and control groups were 19.04% （8/42 eases） and 7. 81% （5/64 eases）, without significant difference （P 〉 0.05 ）. Conclusion Salvia miltiorrhiza injection combined with nimodipine sustained release tablets has a definitive clinical efficacy in the treatment of hypertensive hemorrhagic stroke, which can improve the absorption of hematoma, without increasing the incidence of adverse drug reactions.

关 键 词：丹参注射液 尼莫地平缓释片 高血压出血性脑卒中 安全性 

分 类 号：R972[医药卫生—药品]