CCAAT增强子结合蛋白-α在结肠癌中的表达及意义  

Expression of CCAAT-enhancer-binding proteins in colon cancer and its significance

作　　者：陈旭权 周宏众[2] 倪艳乐 张智勇 叶龙 CHEN Xu - quan ZHOU Hong - zhong NI Yan - le ZHANG Zhi - yong YE Long(a. Department of General Surgery b. The Operating Room, The Second People＇ s Hospital of Leqing City, Leqing 313200, Zhejiang Province, China 2. Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China)

机构地区：[1]乐清市第二人民医院普外科,浙江乐清313200 [2]温州医科大学附属第一医院胃肠外科,浙江温州325000 [3]乐清市第二人民医院手术室,浙江乐清313200

出　　处：《中国临床药理学杂志》2017年第8期745-747,共3页The Chinese Journal of Clinical Pharmacology

基　　金：乐清市科技计划基金资助项目(2014Y005)

摘　　要：目的观察CCAAT/增强子结合蛋白-α(C/EBPα)在结肠癌组织中的表达量变化及其临床意义。方法用Western blot法分别对41例结肠癌患者的癌组织和对应的癌旁正常组织中的C/EBPα的表达情况进行检测,并对C/EBPα的表达和结肠癌的临床病理参数、预后生存率之间的关系进行统计分析。结果 41例正常癌旁组织中,C/EBPα出现低表达2例,高表达39例,低表达率为4.88%;41例结肠癌组织中,C/EBPα出现低表达32例,高表达9例,低表达率为78.05%。结肠癌组织中C/EBPα的低表达率与正常癌旁组织相比,差异有统计学意义(P<0.05)。41例结肠癌组织中,C/EBPα的表达与结肠癌患者的性别、年龄、肿瘤大小及结肠癌的组织学分类等临床病理参数无关(P>0.05),但和结肠癌的原发灶-淋巴结-远处转移(TNM)分期有着密切的关系(P<0.05)。低表达组和高表达组患者的中位生存时间分别为31.5,54.2个月,差异有统计学意义(P<0.05)。结论 C/EBPα在结肠癌中低表达,与结肠癌的TMN分期和预后生存率有着密切关系,对今后结肠癌的早期诊断和靶向治疗有着重要意义。Objective To explore the expression and clinical signifi- cance of CCAAT - enhancer - binding proteins （C/EBPoL） in colon cancer tissues. Methods The expression level of C/EBPct in colon cancer tissues and corresponding non - tumor normal tissues of 41 colon cancer patients was detected by Western blot. The correlation between the expression of C/EBPα and clinicopathological parameters of colon cancer and survival rate of prognosis were statistically analyzed, Results In 41 cases of normal tissue adjacent to carcinoma, low expression of C/EBPα appeared only 2 cases, high expression 39 cases, low expression rate was only 4. 88%; and in 41 cases of colon cancer, C/EBP low expression appeared 32 cases, high expression only 9 cases, low expression rate was 78.05%. Compared with normal adjacent tissues, the expression of C/EBP in colon cancer was down regulated （P〈0. 05）. In 41 cases of colon cancer, independent of C/EBPα expression and colon cancer, cancer size, sex, age and histological classification of colon cancer clinical （P 〉 0.05 ）, but tumor node metastasis （TNM） pathological parameters and colon cancer staging was closely related （ P 〈 0. 05 ）. The median survival times in low expression and high expression groups were 31.5 and 54. 2 months, with significant difference （P 〈 0. 05 ）. Conclusion The low expression of C/EBPα in colon cancer has a close relationship with TMN staging and survival rate of prognosis, which has a great significance on early diagnosis and targeted therapy of colon cancer in the future.

关 键 词：结肠癌 表达 预后 

分 类 号：R968[医药卫生—药理学]