补肾调肝法治疗脾肾阳虚型难治性肾病综合征临床观察  

Clinical Observation on Invigorating Kidney for Regulating Liver Therapy in the Treatment of Refractory Nephrotic Syndrome Due to Yang Deficiency of Spleen and Kidney Type

作　　者：詹继红[1] 胡茂蓉 谢恂[1] 

机构地区：[1]贵阳中医学院第一附属医院肾内科,贵阳550001

出　　处：《中国中医药现代远程教育》2017年第5期81-83,共3页Chinese Medicine Modern Distance Education of China

基　　金：国家中医药管理局全国名老中医药专家传承工作室项目;贵州省中医药科研专项课题【No:QZYY-2014-003】

摘　　要：目的对比观察补肾调肝法治疗脾肾阳虚型难治性肾病综合征的临床疗效。方法纳入符合西医难治性肾病综合征诊断标准并同时符合中医水肿脾肾阳虚型诊断标准者53例,病程为(16±4)个月,年龄18~68岁,将符合纳入标准的53例患者随机分成3组,治疗1组18例,治疗2组18例,对照组17例,3组均采用常规治疗(低盐饮食、蛋白质入量为0.8~1.0/Kg/日,口服甲泼尼龙,降压、降脂、利尿),治疗1组在常规治疗基础上加服中药温肾疏导方(每天2次,每次100 ml);治疗2组在常规治疗基础上加服中成药金匮肾气丸(每次5 g,每日2次,北京同仁堂科技发展股份有限公司制药厂国药准字Z11020147);对照组给予西药常规治疗。4周为1个疗程,连续治疗8周后统计疗效。结果治疗1组误纳入1例,脱落2例(治疗2组脱落1例,对照组脱落1例)。治疗1组显效6例,有效9例,无效2例;治疗2组显效4例,有效7例,无效6例;对照组显效0例,有效4例,无效12例,治疗组优于对照组(P<0.05)。结论温肾疏导方治疗脾肾阳虚型肾病综合征,临床疗效显著,无明显毒副作用。Objective To compare the clinical effect of invigorating kidney and regulating liver therapy in the treatment of refractory nephrotic syndrome due to yang deficiency of spleen and kidney. Methods A total of 53 cases of patients accord with Western medicine refractory nephrotic syndrome diagnostic criteria and TCM diagnostic criteria of yang deficiency of spleen and kidney ede- ma, duration was 16 ＋ 4 months of age 18-68 met the inclusion criteria were selected, and they were randomly divided into 3 groups, with 18 cases in the treatment A group, 18 cases in the treatment B group and 17 cases in the control group. Three groups were giv- en routine treatment （low salt diet, protein intake of 0.8-1.0/kg/day, oral methylprednisolone, antihypertensive, lipid-lowering and diuretic） . The treatment A group was given additionally Wenshen Shudao recipe （2 times every day, 2 100ml） . The treatment B group was given additionally Jingui Shenqi pills （5g each time, 2 times daily, Beijing Tongrentang technology development Limited by Share Ltd pharmaceutical factory national drug approval number z11020147） . The control group was given conventional Western medicine treatment. 4 weeks was a course of treatment. The therapeutic effect after 8 weeks of continuous treatment was analyzeA. Results The treatment A group included 1 case was error, 2 cases were off （treatment B group had 1 case off, control group had 1 ease off） . In the treatment A group, 6 cases had significant effect, 9 cases were effective, and 2 cases were invalid. In the treatment B group, 4 cases had significant effect, 7 cases were effective, and 6 cases were invalid. In the control group, 0 cases had significant effect, 4 cases were effective, and 12 cases were invalid. The treatment group was better than the control group （P 〈 0.05） . Con- clusion The invigorating kidney for regulating liver therapy in the treatment of refractory nephrotic syndrome due to yang deficiency of spleen and kidney type has an obvious clinical curative effect

关 键 词：难治性肾病综合征 对比研究 老中医经验 水肿 虚劳 

分 类 号：R277.5[医药卫生—中医学]