血清肝胆酸、总胆汁酸及血脂水平检测在妊娠期肝内胆汁淤积症中的临床意义  

Clinical significance of combined measuring of serum cholyglycine,total bile acid and blood lipid in intrahepatic cholestasis during pregnancy

作　　者：乔晓亮[1] 

机构地区：[1]郑州市妇幼保健院检验科,郑州450000

出　　处：《医药论坛杂志》2017年第3期43-45,共3页Journal of Medical Forum

摘　　要：目的探讨血清肝胆酸(CG)、总胆汁酸(TBA)及血脂水平检测在妊娠期肝内胆汁淤积症(ICP)中的临床意义。方法选择95例妊娠期胆汁淤积症患者(ICP组)及70例正常妊娠孕妇(对照组)为研究对象,分别检测血清CG、TBA、甘油三脂(TG)、总胆固醇(CHOL)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)谷丙转氨酶(ALT)、谷草转氨酶(AST),并对结果进行分析比较。结果 IPC组血清CG、TBA、TG、CHOL、LDL、ALT及AST水平明显高于对照组,差异具有统计学意义(P<0.05);血清HDL水平显著低于对照组,差异具有统计学意义(P<0.05);Person相关分析表明,ICP患者血清CG及TBA与TG和LDL成正相关(r=0.685,0.722,0.676,0.646,P<0.05),与HDL成负相关(r=-0.463,-0.514,P<0.05)。结论妊娠胆汁淤积症时,血清CG、TBA及血脂水平明显升高,可以作为IPC诊断的敏感指标。Objective The aim of this study was to research the significance of detection of serum cholyglycine （CG） ,to- tal bile acid（TBA） and blood lipid in intrahepatic cholestasis of pregnancy（ICP）. Methods Totally 95 gestational patients of ICP and 70 Normal pregnancy pregnant women （controlgroup） were chosen. Indexs inciding CG, TBA, TG, CHOL, HDL, LDL,ALTandAST were detected, And the results are compared. Results In ICP group,the levels of ser- um CG, TBA, TG, LDL, ALTandAST all were obviously higher than those in the normal control group, and the differences were statistically significant（P 〈0. 05） ; The levels of serum HDL were obviously littler than those in the normal control group（P 〈 0. 05）. The Person correlation analysis showed that patients with ICP serum CG and associates with TG and LDL into positive correlation, Negative correlation with HDL. Conclusions The level of Serum CG, TBA and blood lip- id in intrahepatie cholestasis of pregnancy is significantly increased and can be sensitive indicators of gestaional diabetes in intrahepatie cholestasis of pregnancy, early diagnosis and monitoring of ICP has important clinical significance.

关 键 词：肝胆酸 总胆汁酸 血脂 妊娠胆汁淤积症 

分 类 号：R446.1[医药卫生—诊断学]