上海市浦东新区高尿酸血症流行状况及其危险因素研究  

Prevalence and risk factors of hyperuricemia in Pudong new district of Shanghai

作　　者：刘晓琳[1] 顾建钧 阮晓楠[1] 周先锋[1] 肖林海[1] 吴抗[1] 邱桦[1] 于思雨[1] 芮欣忆[1] 王小楠[1] 柯居中[1] 毕文婕[1] 郝莉鹏 孙乔[1] 周弋[1] 

机构地区：[1]上海市浦东新区疾病预防控制中心-复旦大学浦东预防医学研究院慢性病防治科,上海200136 [2]上海市浦东新区卫生和计划生育委员会

出　　处：《中国慢性病预防与控制》2017年第3期165-170,共6页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金："区卫计委2014年优秀青年人才"项目(PWRq2014-19)

摘　　要：目的了解上海市浦东新区高尿酸血症(HUA)的患病率,探讨影响该地区人群血尿酸水平因素。方法于2013年1-7月采用多阶段分层随机抽样方法抽取9 294名20~80岁常住居民,并对其进行横断面调查,收集空腹静脉血检测血尿酸、血脂、血糖、肾功能等指标,同时进行问卷调查和体格检查。采用SPSS 22.0统计软件进行t检验、χ~2检验和logistic回归分析。结果调查对象HUA患病率为15.54%,其中男性为18.83%,明显高于女性(13.64%),差异有统计学意义(P<0.05)。男性在20~29岁年龄段HUA患病率最高(25.81%),之后随年龄增加患病率逐渐降低,50岁之后略有升高;女性HUA最高患病率出现在70~80岁年龄段(24.37%),40岁之后患病率明显升高;小学及以下学历者HUA患病率最高(18.62%),其次为高中教育程度者(16.22%);与生活行为习惯良好者相比,经常夜班、有吸烟和饮酒习惯的调查对象HUA患病率较高,差异均有统计学意义(P<0.01);有糖尿病、高血压、血脂异常、慢性肾病或向心性肥胖的调查对象HUA患病率分别为20.10%、22.46%、20.87%、21.43%和21.24%,明显高于无上述疾病状态的调查对象(分别为14.47%、10.81%、10.57%、14.12%和8.85%),差异均有统计学意义(P<0.01);肥胖者HUA患病率最高(29.17%),其次为超重者(16.71%),差异有统计学意义(P<0.01)。多因素分析显示,饮酒(OR=1.370,95%CI:1.151~1.631)、患高血压(OR=1.708,95%CI:1.512~1.930)、血脂异常(OR=1.712,95%CI:1.514~1.935)、慢性肾病(OR=1.546,95%CI:1.346~1.776)、超重和肥胖[OR值分别为1.461(95%CI:1.233~1.732)和2.498(95%CI:2.045~3.051)]以及向心性肥胖(OR=1.495,95%CI:1.273~1.755)为HUA的危险因素,女性(OR=0.768,95%CI:0.669~0.881)为HUA的保护因素。结论上海市浦东新区HUA患病率较高,年龄及性别差异影响HUA患病率,维持理想体质指数、血压及血脂水平等在防治HUA中起重要作用。Objective To investigate the morbidity and risk factors of hyperuricemia （HUA） in Pudong new district of Shanghai for exploring the blood uric acid level of the residents.Methods During January-July of 2013,the multi-stage stratified random sampling method was used to select 9 294 residents （20-80 years old） for a cross-sectional study.The investigation was performed with questionnaire,physical examination and blood tests （uric acid,blood lipid,blood glucose and kidney function）.The t test,x2 test and logistic regression analysis were used to analyze the data with SPSS 22.0 software.Results The morbidity of HUA was 15.54%,male morbidity （18.83%） was significantly higher than female morbidity （13.64%） （P〈0.05）.The HUA morbidity （25.81%）of males （20-29 years old） was the highest for males,then male morbidity decreased with age until 50 years old.The female HUA morbidity increased after 40 years old,and the HUA morbidity （24.37%） of females （70-80 years old） was the highest for females.According to education levels,the HUA morbidity （18.62%） of residents with high school level （≤ primary school level） was the highest,secondly the HUA morbidity of residents with high school level was 16.22%.As compared with residents with good life style,the HUA morbidity of residents with smoking,drinking and night shift increased significantly （P〈0.01）.The HUA morbidities of residents with T2DM,hypertension,dyslipidemia,chronic kidney disease and c-obesity were 20.10%,22.46%,20.87%,21.43% and 21.24%,respectively,which were significantly higher than those （14.47%,10.81%,10.57%,14.12% and 8.85%） of residents without any disease （P〈0.01）.The HUA morbidity （29.17%） of residents with obesity was the highest,secondly the HUA morbidity of residents with overweight was 16.71% （P〈0.05）.Multivariable logistic regression analysis showed that drinking （OR=1.370,95%CI：1.151-1.631）,hypertension （OR=1.780,95%CI：1.512-1.930）,dyslipidemia （OR=1.712,95%CI：1

关 键 词：高尿酸血症 患病率 危险因素 

分 类 号：R181.3[医药卫生—流行病学]