老年糖尿病肾病病人口腔牙周健康状况及炎性因子水平调查研究  

Investigation of periodontal health and the level of inflammatory factors in elderly patients with diabetic nephropathy

作　　者：朱艳香[1] 刘文国[2] 宋雪冬[2] 

机构地区：[1]廊坊市第四人民医院耳鼻喉科,河北省廊坊市065700 [2]廊坊市第四人民医院检验科,河北省廊坊市065700

出　　处：《实用老年医学》2017年第4期373-376,共4页Practical Geriatrics

摘　　要：目的调查老年糖尿病肾病病人口腔牙周健康状况及炎性因子水平。方法以46例老年糖尿病肾病病人为糖尿病肾病组,40例老年2型糖尿病病人为糖尿病组,另选择体检健康的老年人39例为对照组。3组均接受口腔牙周健康状况检查及外周血、龈沟液白介素-1β(IL-1β)、IL-6及肿瘤坏死因子-α(TNF-α)水平检测。结果 (1)糖尿病肾病组牙周炎患病率为93.48%(43/46),明显高于糖尿病组的57.50%(23/40)及对照组的28.21%(11/39),差异均有统计学意义(P均<0.05)。糖尿病肾病组龈沟出血指数(SBI)、牙齿填充指数(DMFT)、简化口腔卫生指数(OHI-S)、牙周袋探诊深度(PD)、临床附着丧失(CAL)、牙松动度明显高于糖尿病组及对照组(P均<0.05)。(2)糖尿病肾病组外周血及龈沟液IL-1β、IL-6及TNF-α水平均明显高于糖尿病组及对照组(P均<0.05)。结论老年糖尿病肾病病人口腔健康状况较差,牙周炎患病率及炎性因子水平较高。Objective To study the prevalence of periodontal disease and the level of inflammatory factors in elderly patients with diabetic nephropathy. Methods forty-six elderly patients with diabetic nephropathy were choosed as diabetic nephropathy group, 40 elderly patients with type 2 diabetes were selected as diabetes group, and 39 healthy old people were selected as control group. The oral and periodontal health status were surveyed, and the the levels of interleukin-1β （ IL-β）, IL-6, tumor necrosis factor（TNF-α） in peripheral blood and fluid of gingiva groove were detected in three groups. Results （1）The prevalence rate of periodontitis was 93.48% （43/46） in diabetic nephropathy group, and was significantly higher than that in diabetes group （57.50%, 23/40） and control group （28.21%, 11/39）, the differences between three groups were statistically significant （P〈0. 05）. Gingival sulcus bleeding index （SBI）, teeth filling index （ DMFT）, simplify oral hygiene index （ OHI-S）, periodontal pocket probing depth （PD）, clinical attachment loss （CAL）, tooth mobility in diabetic nephropathy group were significantly higher than those in diabetes group and control group （P〈0. 05）. （2）The levels of IL-1β, TL-6,TNF-α of peripheral blood and fluid of gingiva groove in diabetic nephropathy group were significantly higher than those in diabetes group and control group（P〈0. 05）. Conclusions The oral health status are worse, the prevalence of periodontitis and the level of inflammatory factors are higher in elderly patients with diabetic nephropathy.

关 键 词：糖尿病肾病 老年人 牙周炎 炎性因子 

分 类 号：R587.2[医药卫生—内分泌]