LEPR基因多态性与未绝经女性BMI变化的关系研究  

Association between the genetic polymorphisms of the LEPR and Body Mass Index( BMI) change among premenopausal women

作　　者：刘春容[1] 李卉[1] 严兰平 帅平[3] 徐珠屏 熊萍[1] 袁雪莲[1] 赵敏[1] 李佳圆[1] 

机构地区：[1]四川大学华西公共卫生学院(华西第四医院),四川成都610041 [2]成都双流妇幼保健院,四川成都610200 [3]四川省人民医院,四川成都610072

出　　处：《现代预防医学》2017年第9期1602-1606,共5页Modern Preventive Medicine

基　　金：国家自然科学基金(项目批准号:81302500);项目名称:联合应用CART及BP-ANN法建立中国西部汉族女性乳腺癌环境-基因风险评估模型的研究;成都市科技惠民项目(立项编号:2015-HM01-00049-SF);项目名称:成都市城镇社区女性乳腺癌环境-遗传分级风险评估研究

摘　　要：目的探讨瘦素受体(LEPR)基因多态性与未绝经女性近5年体质指数(BMI,)变化之间的关系。方法采用横断面研究,于2015年3月~6月收集四川省人民医院体检中心和成都双流区妇保院体检中心未绝经健康女性463人,收集其一般人口学特征、人口测量指标、日均能量摄入等信息,以5年前BMI与现在的BMI变化情况将研究对象分为低风险组(BMI5year<24 kg/m^2→BMI_(present)<24 kg/m^2&BMI_5year≥24 kg/m^2→BMI_(present)<24 kg/m^2)、增重至超重组(BMI_5year<24kg/m^2→BMI_(present)≥24kg/m)、持续超重/肥胖组(BMI_5year≥24 kg/m2→BMI_(present)≥24kg/m^2)。采用飞行时间质谱检测LEPRrs1137100,LEPRrs1137101基因型。采用多分类Logistic回归,估计LEPR基因多态性与未绝经健康女性人群近5年BMI变化的关联值(OR)。结果 LEPR rs1137100和LEPR rs1137101突变等位基因的携带率分别为83.3%和89.0%;调整重要的混杂因素后,携带LEPRrs1137100AA+AG或LEPRrs1137101AA+AG可增加发生持续超重/肥胖的风险(OR=1.67,95%CI:1.02-2.73;OR=1.76,95%CI:1.01-3.07)。结论LEPRrs1137100和LEPRrs1137101基因多态性可能与未绝经女性持续超重/肥胖有关。Objective To investigate the association between the polymorphisms of the LEPR genes and body mass index （BMI） change in the latest 5 years in premenopausal women. Methods Cross - sectional study was designed. From March to June in 2015,a total of 463 healthy premenopausal women were collected, and their demographic characteristics, anthropometric variables and energy intake were gathered. According to the BMI of present and 5 years ago, the subjects were divided into three groups：low risk （ BMIsyear 〈 24kg/m2 → BMIpresent〈 24kg/m2 ＆BMIsyear ≥ 24 kg/m2 → BMIpresent 〈 24kg/m2 ）, weight to overweight （ BMI5 year 〈 24kg/m2→BMIpresent ≥ 24kg/m2 ） and persistent overweight/obesity （ BMI5 yearkg/m2→BMIpresent ≥ 24 kg/ m2）. Flight Mass Spectrometer was used to detect the LEPRrs1137100, LEPRrs1137101 genotypes. The associations between genetic variations in the LEPR genes and body mass index（BMI） change in latest 5 years were assessed by muhinomial logistic model. Results The carrying rate of LEPRrsl137100AA ＋ AG and LEPRrsl137101AA ＋ AG were 83. 3% and 89.0% respectively. After Adjusting important confounders, carrying LEPRrsl137100AA ＋ AG or LEPRrs1137101AA ＋ AG would increase the risk of persistent overweight/obesity （ OR = 1.67,95% CI： 1.02 - 2.73 ; OR = 1.76,95% CI： 1. 01 - 3.07 respectively）. Conclusion The polymorphisms of LEPRrsl137100,LEPRrs1137101are associated with persistent overweight/ obesity of premenopansal women.

关 键 词：瘦素受体基因多态性 未绝经女性 体质指数(BMI)变化 

分 类 号：R17[医药卫生—妇幼卫生保健]