转录因子7类似物-2基因rs12255372多态性与妊娠期糖尿病发病风险的系统评价  

Systematic evaluation of TCF7L2 rs12255372 polymorphism and the gestational diabetes mellitus risk

作　　者：申超燕 樊洁华 陈丹丹[1] 彭凌湘[2] 陈再明[3] 陆雪萍 秦秀妹[5] 王玉春[5] 秦吉秀 文爱珍[3] 唐玲芳 石青峰[2] 余红平[1] 于祥远[1] 

机构地区：[1]桂林医学院公共卫生学院流行病学教研室,广西桂林541004 [2]桂林医学院第一附属医院,广西桂林541004 [3]桂林市灵川县人民医院,广西桂林541299 [4]桂林市妇女儿童医院,广西桂林541001 [5]桂林医学院第二附属医院,广西桂林541004

出　　处：《现代预防医学》2017年第9期1607-1612,共6页Modern Preventive Medicine

基　　金：大学生创新创业训练计划项目(201510601079);广西教育厅高校科研项目(KY2015YB223);广西科学研究与技术开发计划项目(桂科攻14124004-1-15)

摘　　要：目的探讨转录因子7类似物-2(TCF7L2)基因rs12255372 G>T多态性与妊娠期糖尿病(GDM)发病风险的关系。方法截止2016年9月,检索NCBI Pub Med、中国知网(CNKI)及万方等数据库关于rs12255372多态性与GDM发病相关病例-对照研究。Stata12.0软件检测所纳入数据发表偏倚及异质性,以合并效应的OR及95%置信区间(95%CI)评估rs12255372位点与GDM的发病风险。结果依据纳入、排除标准,共9篇文献,包含5778例研究对象纳入本研究。Meta分析显示,与G基因型相比,T等位基因携带者GDM发病风险显著增高,整体合并效应的OR值及95%CI为1.28(1.16~1.40);以种族进行亚组分析,高加索人群合并效应的OR及95%CI为1.29(1.15~1.45),亚洲人群为1.25(1.05~1.48)。基因型分析显示,显性遗传模型下,rs12255372 G>T与GDM发病显著相关,与GG基因型相比,GT+TT基因型携带者GDM发病风险显著增高,整体合并效应的OR及95%CI为1.35(1.20~1.53),高加索人群为1.39(1.20~1.62),亚洲人群为1.28(1.04~1.58)。结论 TCF7L2rs12255372 G>T多态性与GDM发病密切相关,G(T突变可能增加妊娠期妇女GDM的发病风险。Objective To investigate the association between the polymorphism of transcription factor 7 - like 2 （TCFTL2） gene polymorphism rs12255372 G 〉 T and the risk of gestational diabetes mellitus（GDM）. Methods Case - control studies on the association between rs12255372 G 〉 T polymorphism on GDM risk were searched by using the NCBI PubMed, CNKI and Wanfang database before September 2016. Stata12.0 software was adopted to detect the publication bias and heterogeneity across the included study ,and the combined OR with corresponding 95% CI was used to assessing rs12255372 and GDM risk. Results According to the inclusion and exclusion criteria, totally 9 studies with 5778 subjects were included. Meta - analysis showed that comparing with G allele,rs12255372 T allele could significantly increase the risk of GDM, and the combined OR and corresponding 95% CI were 1.28（ 1.16 - 1.40） in overall. Subgroup analysis by ethnic showed that the combined OR and corresponding 95% CI were 1.29 （ 1.15 ~ 1.45 ） in Caucasians and 1.25 （ 1.05 - 1.48 ） in Asians. Genotype analysis showed that rs12255372 G 〉 T was significantly associated with the risk of GDM in the dominant model. Compared with the GG genotype, the GT ＋ TT genotype carriers had a significantly higher risk of GDM, and the combined OR and 95% CI were 1.35 （ 1.20 ~ 1.53 ） in overall, and 1.39 （ 1.20 - 1.62 ） in Caucasians and 1.28 （ 1.04 ~ 1.58 ） in Asians. Conclusion TCF7L2 rs12255372 G 〉 T polymorphism are closely related to the risk of GDM, and G （ T variant may increase the GDM risk in pregnant women.

关 键 词：TCF7L2基因 多态性 妊娠期糖尿病 发病风险 

分 类 号：R17[医药卫生—妇幼卫生保健]