系统性红斑狼疮肝损害的临床特点和相关危险因素分析  

Analysis of clinical characteristics and risk factors of liver damage in patients with systemic lupus erythematosus

作　　者：钟彩玲[1] 观美华[1] 高利霞[1] 王飞[1] 陈艳[1] 

机构地区：[1]广东省湛江中心人民医院,广东湛江524000

出　　处：《中国医药科学》2017年第5期191-193,196,共4页China Medicine And Pharmacy

摘　　要：目的观察系统性红斑狼疮(SLE)肝损害在临床上的特点,并分析相关危险因素。方法以我院2007年7月~2015年8月的286例SLE患者为研究对象,对SLE肝损害及无肝损害的患者进行基本情况的比较,观察临床特点,对危险因素结合Logistic回归分析予以研究。结果在神经精神性狼疮、病程≤3个月、血液系统损害、C3体四个项目中,肝损害组(25.0%、60.7%、75.0%、55.4%)均比无肝损害组(5.0%、34.9%、48.2%、23.4%)高,差异有统计学意义(P<0.05);Logistic回归分析表明,上述四个项目均为SLE肝损害的危险因素。结论影响肝损害的显著危险因素有神经精神性狼疮、病程≤3个月、血液系统损害、不提C3,应对其加强重视。Objective To analyze clinical characteristics and risk factors of liver damage in patients with systemic lupus erythematosus. Methods 286 cases with SLE in our hospital from July 2007 to August 2015 were selected as the study objects,to compare the basic situation of SLE patients with liver damage and no liver damage,to observe clinical characteristics,and analyze the risk factors by Logistic regression. Results In the nervous and systemic lupus erythematosus,the duration of less than 3 months,blood system damage, and complement C3,1iver damage group （ 25.0%,60.7%,75.0%,55.4% ） were higher than non-liver damage （ 5.0%,34.9%,48.2%,23.4% ）,which showed significant differece（P 〈 0.05）;Logistic regression showed that the above four projects were risk factors of liver damage. Conclusion Risk factors of liver damage include the nervous and systemic lupus erythematosus,the duration of less than 3 months,blood system damage, and complement C3,should pay attention.

关 键 词：系统性红斑狼疮 肝损害 危险因素 临床特点 LOGISTIC回归分析 

分 类 号：R593.2[医药卫生—内科学]