间苯三酚注射液在反复着床失败患者胚胎移植中的应用  

Application of phloroglucinol injection in embryo transfer in patients with recurrent implantationfailure

作　　者：张译升[1] 李宁[2] 池艳[1] 覃捷[1] 谭卫红[1] 成俊萍[1] 夏小灵 黄泰帅 何冰[1] 

机构地区：[1]广西壮族自治区人民医院生殖中心,南宁530021 [2]广西医科大学,南宁530021

出　　处：《中国医师杂志》2017年第4期487-490,494,共5页Journal of Chinese Physician

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费课题（Z2015320,Z2015344）

摘　　要：目的观察间苯三酚对胚胎反复着床失败（RIF）患者妊娠结局的影响。方法选取本中心RIF患者146例，按照入组顺序分为两组，观察组使用间苯三酚，对照组不使用间苯三酚。比较两组患者生化妊娠率、临床妊娠率、胚胎着床率、流产率及活产率等指标。结果观察组RIF患者生化妊娠率显著高于对照组（57．9％VS36．8％，P〈0．05），观察组较对照组临床妊娠率、着床率、活产率升高，流产率降低，但差异均无统计学意义（P〉0．05）。结论应用间苯三酚，可提高RIF患者生化妊娠率。Objective To investigate the effect of phloroglucinol on pregnancy outcome in patients with recurrent implantation failure （RIF）. Methods A total of 146 patients with RIF from March 2014 to March 2016 from the reproductive medical center of the Guangxi Zhuang Autonomous Region people Hospi- tal was randomly divided into two groups, 73 cases were included in study group [ 16 cases of in vitro fertili- zation and embryo transfer （IVF-ET） and 57 cases of frozen/thawed embryo transfer （FET） ]. Patients in study group were given intramuscular injection of phloroglucino140mg, two times a day before the transplan- tation day to three days after transplantation, 73 cases without phloroglucinol injection were included as con- trol group. The biochemical pregnancy rate, clinical pregnancy rate, embryo implantation rate, abortion rate, ectopic pregnancy rate, multiple pregnancy rate and live birth rate were compared between two groups. Results The biochemical pregnancy rate in study group of FET was significantly higher than the control group （57. 9% vs 36. 8%, P〈0. 05） ; the biochemical pregnancy rate in study group of IVF-ET was higher than the control group （50% vs 37.5% , P 〉 0.05 ）, but there was no significant difference between the study group and control group; compared to the control group, the study group was increased clinical preg- nancy rate, implantation rate, live birth rate, and decreased abortion rate （P 〉 0. 05）, but the difference was not statistically significant. Conclusions The application of phloroglucinol in women with RIF may im- prove the biochemical pregnancy rate. esneciallv in FET cvcles.

关 键 词：间苯三酚/治疗应用 胚胎移植 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]