马拉色菌外分泌物的研究进展  

Extracellular secretions of Malassezia species

作　　者：韩阳[1] 齐瑞群[1] 张雨京[1] 高兴华[1] 

机构地区：[1]中国医科大学附属第一医院皮肤科,沈阳110001

出　　处：《国际皮肤性病学杂志》2017年第3期185-188,共4页International Journal of Dermatology and Venereology

基　　金：国家重点基础研究发展计划（2013CB531604）

摘　　要：马拉色菌为人体皮肤常住菌，亦是条件致病菌。马拉色菌与花斑糠疹、马拉色菌毛囊炎、特应性皮炎、头皮屑、脂溢性皮炎及银屑病等多种皮肤病相关。马拉色菌在生长繁殖过程中会产生多种外分泌物，包括蛋白质及代谢产物等。近年研究多集中在马拉色菌外分泌蛋白中，其中脂肪酶、蛋白酶、磷脂酶、脂氧合酶、过氧化氢酶和酸性磷酸酶等酶类物质的种类、数量、活性可能与马拉色菌的致病相关。马拉色菌外分泌性代谢产物研究较少，malassezin、吲哚［3,2-b］咔唑、β咔啉生物碱等代谢产物与生物体的功能变化有直接的联系。马拉色菌外分泌物的研究，对阐明马拉色菌的致病机制具有指导意义，可能为治疗提供新思路。具有指导意义，可能为治疗提供新思路。Malassezia species are a member of the resident skin flora, and also a conditioned pathogen. Malassezia species have been reported to be associated with various skin diseases, such as pityriasis versicolor, Malassezia folliculitis, atopic dermatitis, dandruff, seborrheic dermatits and psoriasis. Malassezia species can produce a variety of extracellular secretions, including proteins and metabolites. Recent studies have been mainly focused on secretory proteins, such as lipases, proteases, phospholipases, lipoxygenases, catalases and acid phosphatases. The type, quantity and activity of these secretory proteins may be associated with pathogenic mechanisms of Malassezia. Limited research is available on secretory metabolites of Malassezia, and it is considered that some metabolites such as malassezin, indolo[3, 2-b]carbazole and pityriacitrin are directly related to biological functions. To study extracellular secretions of Malassezia species may help to clarify their pathogenic mechanisms and provide novel ideas for treatment of related diseases.

关 键 词：马拉色菌属 蛋白质类 机会致病菌感染 代谢产物 外分泌物 

分 类 号：R756[医药卫生—皮肤病学与性病学]