阿托伐他汀联合依折麦布治疗老年冠心病合并高脂血症临床疗效观察  

Clinical Effect of Atorvastatin and Ezetimibe in the Treatment of Coronary Heart Disease with Hyperlipidemia in Elderly Patients

作　　者：冷良[1] 刘卫红[1] 

机构地区：[1]华中科技大学附属协和医院,武汉430056

出　　处：《中西医结合心脑血管病杂志》2017年第7期839-841,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的研究阿托伐他汀联合依折麦布(益适纯)治疗老年冠心病合并高脂血症的临床效果。方法选择2012年8月—2014年9月华中科技大学附属协和医院收治的80例冠心病合并高脂血症老年病人为研究对象,随机分为观察组与对照组,每组40例。在常规治疗方法的基础上,对照组采用阿托伐他汀进行治疗,观察组采用阿托伐他汀联合依折麦布进行治疗。观察两组病人治疗前后的血脂水平、生存质量评分、6 min步行距离的变化及心血管事件发生情况,并比较两组临床疗效。结果与治疗前比较,两组病人总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)均明显降低(P<0.05),高密度脂蛋白胆固醇(HDL-C)均明显升高(P<0.05),其中观察组变化更明显,两组间比较差异有统计学意义(P<0.05);治疗后,两组病人的生存质量评分均明显降低,6 min步行距离明显升高,观察组改善程度明显优于对照组,差异有统计学意义(P<0.05);观察组临床总有效率为92.5%,明显高于对照组的75.0%,差异有统计学意义(P<0.05);两组病人心血管不良事件表现为心肌梗死、缺血性卒中和心源性死亡,其中观察组心血管不良事件总发生率为7.5%,明显低于对照组的27.5%,两组比较差异有统计学意义(P<0.05)。结论阿托伐他汀联合依折麦布治疗老年冠心病合并高脂血症临床效果显著,降低病人血脂水平更明显,可以提高病人的生存质量及6 min步行距离,冠心病的临床总有效率更高,心血管不良事件发生率更低。Objective To study the clinical effect of atorvastatin and ezetimibe(Zetia)in the treatment of coronary heart disease with hyperlipidemia in elderly patients.Methods Eighty elderly patients with coronary heart disease and hyperlipidemia from August 2012 to September 2014 in our hospital were randomly divided into two groups:control group(n =40)treated with routine treatment and atorvastatin,and treatment group(n =40)treated with routine treatment and atorvastatin plus ezetimibe.The level of blood lipid was compared between the two groups before and after treatment.The quality of life and 6-minute walking distance were compared.Total effective rate of coronary heart disease and the incidence of cardiovascular events in the two groups was compared in the two groups.Results Compared with before treatment,the level of total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C)were significantly lower in two groups,the high-density lipoprotein cholesterol(HDL-C)were significantly increased,which was more obviously in treatment group(P <0.05).After treatment,the quality of life was significantly reduced,the 6 min walking distance was significantly higher in two groups,which improved significantly higher in treatment group than that in control group(P <0.05).The total effective rate was92.5%in treatment group,which was significantly higher than that in control group(75.0%,P <0.05).The cardiovascular adverse events was infarction,ischemic stroke and cardiac death.The overall incidence of cardiovascular adverse events was 7.5%in treatment group,which was significantly lower than that in control group(27.5%,P <0.05).Conclusion Atorvastatin and ezetimibe can lower the level of blood lipid,improve the quality of life and 6 min walking distance,and decrease the incidence of cardiovascular adverse events in elderly patients with coronary heart disease and hyperlipidemia.

关 键 词：冠心病 高脂血症 阿托伐他汀 依折麦布 血脂 生存质量 

分 类 号：R541.4[医药卫生—心血管疾病] R256.2[医药卫生—内科学]