孕期监测铁蛋白、血清铁对预测缺铁性贫血的临床意义  

The Clinical Significance of Monitoring Iron Protein and Serum Iron During Pregnancy to Predict Iron Deficiency Anemia

作　　者：唐丹[1] 巨根 李红梅[1] 

机构地区：[1]延安大学附属医院妇产科,陕西延安716000

出　　处：《湖北科技学院学报（医学版）》2017年第2期121-123,共3页Journal of Hubei University of Science and Technology(Medical Sciences)

摘　　要：目的探讨铁蛋白及血清铁的筛查对早期识别孕期缺铁性贫血的临床意义,了解铁蛋白和血清铁的联合检测对缺铁性贫血的的预测价值。方法随机抽取1035例延安市宝塔区孕妇作为受检对象,运用氯化高铁法(HICN)测定血红蛋白(Hb)水平,胶体金标记免疫层析法测定血清铁蛋白(SF)水平,亚铁嗪比色法原理测定血清铁(SI)水平,并调查所有受检孕妇的年龄、孕产次、身体状况、营养状况、日常饮食等。结果孕妇缺铁性贫血患病率为15.94%,铁蛋白缺乏率为24.25%,后者高出前者8.31%,血清铁缺乏率为11.30%,与贫血患病率接近。孕妇妊娠各期铁蛋白、血清铁缺乏与贫血患病率差异有统计学意义(P<0.05);不同贫血程度与铁蛋白、血清铁含量差异有统计学意义(P<0.05)。结论随妊娠月份增加贫血患病率、铁蛋白及血清铁缺乏率呈上升趋势;其中铁蛋白与血清铁的缺乏程度与贫血程度有关,且贫血程度越严重铁蛋白与血清铁含量越低。在非贫血孕妇中,已有部分孕妇铁蛋白降低,因此铁蛋白可以作为早期反映铁耗竭的指标,且在绝大部分贫血者中几乎都有血清铁的缺乏,因此铁蛋白与血清铁的联合检测对缺铁性贫血的早预测、早发现、早干预具有重要应用临床价值。Objective To investigate the clinical significance of monitoring iron protein and serum iron during Pregnancy so as to predict iron deficiency anemia. Methods 1035 cases of pregnant women in Yanan City Baota District were randomly selected as the subject;The ferric chloride （HICN） method was used for the determination of hemoglobin （ Hb） level, gold immunochromatography assay for serum ferritin （SF） level, and FerroZine colorimetric for determination of serum iron principle （SI） the level of investigation;Other informa-tion such as all pregnant womens age,parity,body condition,nutritional status,and diet was also collected . Re-sults The rate of iron deficiency was 24. 25% , which was 8.31% higher than that （ 15.94%） of iron deficiency anemia in pregnant women. The serum iron deficiency rate was 11.30 % ,and the prevalence rate of anemia was close to that of the patients. There were significant differences in iron protein, serum iron deficiency and anemia prevalence in different stages of pregnancy （P 〈0.05） ;There were significant differences in the levels of ane-mia and iron protein, serum iron levels （P 〈0. 05）. Conclusion With the increasing prevalence of anemia in pregnancy, serum ferritin and iron deficiency rate is on the rise ; the lack of ferritin and serum iron is related to the degree of anemia：The more severe the degree of anemia,the lower the level of iron protein and serum iron. In non anemic pregnant women, some pregnant women of ferritin decreased, therefore ferritin can be used as early indicators of iron depletion index,and in the vast majority of anemia and almost all lack of serum iron, fer-ritin and the combined detection of serum iron on iron deficiency anemia in early prediction, early detection and early intervention with the important clinical application value.

关 键 词：铁蛋白 血清铁 早期识别 孕期贫血 

分 类 号：R556.3[医药卫生—血液循环系统疾病]