阻塞性睡眠呼吸暂停低通气综合征对脑梗死患者认知功能的影响  

Effect of obstructive sleep apnea syndrome on cognition in patients with cerebral infarction

作　　者：张昀赟 陈季志[1] 牛艳芳[1] 查芹[1] 翁秋燕[1] 王美华[1] 

机构地区：[1]宁波大学医学院附属医院神经内科,315000

出　　处：《浙江医学》2017年第8期628-630,共3页Zhejiang Medical Journal

摘　　要：目的分析脑梗死合并阻塞性睡眠呼吸暂停综合征(OSAS)患者认知功能的特点,探讨OSAS对此类患者的影响。方法选择2014年3月至2016年9月住院治疗的脑梗死急性期患者148例。依据多导睡眠图(PSG)监测,分为单纯脑梗死组98例和脑梗死合并OSAS组50例。两组患者分别行蒙特利尔认知评估(MoCA)量表测定和事件相关电位(ERP)P300检测,比较两组患者MoCA总分以及各认知域的分数和P300潜伏期、波幅的测定结果。结果脑梗死合并OSAS组患者视空间与执行功能、命名能力、延迟记忆、注意力、语言、抽象、定向力得分与总分均低于单纯脑梗死组,差异均有统计学意义(P<0.05)。脑梗死合并OSAS组患者P300潜伏期较单纯脑梗死组患者延长,波幅较单纯脑梗死组患者降低,差异均有统计学意义(均P<0.05)。结论 OSAS可加重脑梗死患者认知功能障碍。Objective To investigate the effect of obstructive sleep apnea syndrome（OSAS） on cognition in patients with cerebral infarction. Methods One hundred and forty eight patients with acute cerebral infarction admitted in our hospital from March 2014 to September 2016 were enrolled in the study. According to the results of polysomnography（PSG） monitoring,there were 50 cerebral infarction patients with OSAS（OSAS group） and 98 cases without OSAS（non-OSAS group）. Results BMI and the proportion of male were higher in OSAS group than those in non-OSAS group（P〈0.05）. The overall scores and scores of sub-items in OSAS group were lower than those in non-OSAS group（P〈0.05）. There were significant differences in scores of visual space and executive function,memory,attention,language and abstraction between two groups（P〈0.01）. The latency of P300 in OSAS group was prolonged and the amplitude was decreased（P〈0.01 or P〈0.05）. Conclusion OSAS may aggravate cognitive impairment in patients with cerebral infarction.

关 键 词：阻塞性睡眠呼吸暂停综合征 脑梗死 认知功能障碍 MOCA量表 事件相关电位 

分 类 号：R766[医药卫生—耳鼻咽喉科]