基于4-氟-N′-(3-乙氧基-2-羟基苯亚甲基)苯甲酰肼的甲基麦芽酚和乙基麦芽酚配位的氧钒(Ⅴ)配合物的合成、晶体结构及其类胰岛素活性（英文）  

Syntheses, Crystal Structures and Insulin-like Activity of Maltolato-and Ethylmaltolato-Coordinated Oxovanadium(Ⅴ) Complexes Derived from 4-Fluoro-N′-(3-ethoxy-2-hydroxybenzylidene)benzohydrazide

作　　者：李玲[1] 吕凯文[1] 李运彤 姜贵发[1] 辛雨[1] 叶蕾[1] 张岩[1] 刘慧[1] 商超男 由忠录[1] 

机构地区：[1]辽宁师范大学化学化工学院,大连116029

出　　处：《无机化学学报》2017年第5期905-912,共8页Chinese Journal of Inorganic Chemistry

基　　金：辽宁省自然科学基金(No.2015020673);辽宁师范大学开放实验室(No.cx20160102)资助项目

摘　　要：制备了一个芳酰腙化合物4-氟-N′-(3-乙氧基-2-羟基苯亚甲基)苯甲酰肼(H2L)。利用H2L和VO(acac)2分别与甲基麦芽酚(mat)和乙基麦芽酚(Emat)在甲醇中反应,得到了2个配合物[VO(L)(mat)](1)和[VO(L)(Emat)](2)。通过元素分析、红外光谱、紫外可见光谱和核磁共振氢谱表征了这些化合物的结构。通过单晶X射线衍射进一步确定了化合物的结构。芳酰腙配体以二价阴离子的方式通过酚羟基氧、亚胺基氮和烯醇氧原子与钒原子进行配位。在每个配合物中,钒都采取八面体配位构型。将配合物通过灌胃对正常的大鼠和四氧嘧啶糖尿病大鼠给药2周时间,结果表明这两个配合物在剂量为10.0和20.0 mgV·kg-1时可以显著降低四氧嘧啶糖尿病大鼠的血糖值,而对于正常大鼠的血糖值却没有改变。A new aroylhydrazone compound 4-fluoro-N＇-（3-ethoxy-2-hydroxybenzylidene）benzohydrazide （H2L） was prepared. Reaction of H2L and VO（aeae）2 with maltol（mat） and ethylmaltol（Emat）, respectively, in methanol afforded the complexes [VO（L）（mat）] （1） and [VO（L）（Emat）] （2）. Both H2L and the oxovanadium complexes were characterized by elemental analysis, IR, UV-Vis and JH NMR spectra. The structures of the compounds were further confirmed by single crystal X-ray diffraction. The aroylhydrazone ligand, in its dianionic form, coordinated to the V atoms through the phenolate oxygen, imino nitrogen and enolate oxygen. The maltol and ethylmaltol ligands coordinated to the V atoms through the carbonyl oxygen and deprotonated hydroxyl oxygen. The V atom in each complex is in oetahedral coordination. The complexes were administered intragastrically to both normal and alloxan-diabetic mice for two weeks. The biological activity results show that the complexes at doses of 10.0 and 20.0 mgv kg-l, can significantly decrease the blood glucose level in alloxan-diabetic mice, but the blood glucose level in the treated normal mice was not altered.

关 键 词：钒配合物 芳酰腙 晶体结构 类胰岛素活性 

分 类 号：O614.511[理学—无机化学]