老年2型糖尿病患者血清甲基乙二醛、脑源性神经营养因子与认知功能的相关性研究  

Correlation of serum methylglyoxal and brain-derived neurotrophic factor with cognitive function in elderly patients with type 2 diabetes mellitus

作　　者：孙波[1] 任建功[1] 尹虹[1] 罗晖[1] 胡雪剑[1] 杨燕[1] 

机构地区：[1]兰州大学第二医院糖尿病二科,730050

出　　处：《中华内分泌代谢杂志》2017年第4期307-311,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：2015年兰州市科技局项目

摘　　要：目的探讨老年2型糖尿病患者的血清脑源性神经营养因子（BDNF）、甲基乙二醛（MG）水平与认知功能的相关性。方法本研究将正常人群与老年2型糖尿病患者按照年龄、性别及文化程度进行频数匹配，对2组入选人群以酶联免疫吸附法（ELISA）检测BDNF，采用HPLC法检测MG，以重复性成套心理状态测验（RBANS）检测认知功能。结果（1）与对照组相比，2型糖尿病组的血清BDNF水平明显下降[（4．97±3．05对11．77±7．92）ng／ml，P〈O．01]，血清MG水平升高[（67．91对43．86）nmol/L，P〈0．05]，并且血清MG升高的水平与血清BDNF下降水平具有一定的相关性。（2）与对照组相比，2型糖尿病组在认知量表标准化测验总分、视觉广度、即刻记忆、延时记忆和注意力方面的得分下降较为明显（均P〈0．05），经过多元回归调整影响因素后，血清BDNF水平与认知量表标准化总分、延时记忆和注意功能的关联依然明显：2型糖尿病组患者血清MG水平与延迟记忆力、即刻记忆力以及量表标准化总分存在相关性（P〈O．05）。（3）血清BDNF与MG水平呈显著负相关（P=0．031）。结论老年2型糖尿病患者的认知功能与血清MG、BDNF水平具有一定的相关性，MG升高与BDNF的下降可能参与了认知功能损伤的发病过程。Objective To investigate the association of serum brain-derived neurotrophic factor （BDNF） and methylglyoxal （MG） levels with cognitive function in elderly patients with type 2 diabetes mellitus （ T2DM ）. Methods The normal population and elderly patients with T2DM were frequency-matched by age, sex, and educational level. BDNF was detected by ELISA assay, MG by HPLC assay, and cognitive function by sets of repetitive mental state examination （RBANS） in the two groups. Results （ 1 ） Compared with control group, serum BDNF level in T2DM group was significantly decreased [ （4.97 ±3.05 vs 11.77 ± 7.92 ） ng/ml, P〈0.01] while serum MG level was elevated [ （ 67.91 vs 43.86 ） nmol/L, P〈0.05 ]. The increasing of serum MG was related to the decreasing of serum BDNF. （2） Compared with control group, the scores for standardized tests of cognitive scale, visual breadth, immediate memory, delayed memory, and attention areas in T2DM group were significantly decreased （all P 〈 0.05 ）. After the influencing factors were adjusted by multiple regression, the associations of serum BDNF level with cognitive scale standardized score, the delay associated with memory and attention functions were still evident, and serum MG level in T2DM group was still related with the levels of delayed memory, immediate memory, total scale standardization （all P 〈 0. 05 ）. （3） Serum BDNF level was negatively correlated with serum MG level （P = 0.031）. Conclusions Cognitive function of elderly patients with T2DM is related with serum MG and BDNF levels. The increased serum MG as well as the decreasd serum BDNF levels maybe involved in the pathogenesis of impaired cognitive function.

关 键 词：老年人 糖尿病 2型 认知功能 甲基乙二醛 脑源性神经营养因子 

分 类 号：R587.1[医药卫生—内分泌]