ABO血型与急性心肌梗死的相关性  

Correlation between ABO blood group and acute myocardial infarction

作　　者：梁普博[1] 袁月荣[1] 郑云龙[1] 苏丹霞[1] 赵红娟[1] 

机构地区：[1]广东省农垦中心医院心血管内科,广东湛江524002

出　　处：《岭南心血管病杂志》2017年第2期147-150,共4页South China Journal of Cardiovascular Diseases

摘　　要：目的探讨ABO血型与急性心肌梗死的相关性。方法将确诊为急性心肌梗死的386例患者设为观察组,再选取同期门诊体检健康者412名设为对照组;分别测定两组中ABO血型、空腹血糖(FBG)、血脂等生化指标;运用Logistic多元回归分析等统计学方法分析患者ABO血型与急性心肌梗死相关性。结果与对照组比较,观察组的低密度脂蛋白胆固醇(LDL-C)浓度[(2.91±1.12)mmo/L vs.(2.55±1.03)mmo/L,t=4.730,P<0.05]、空腹血糖浓度[(6.76±4.85)mmo/L vs.(4.53±1.26)mmo/L,t=8.761,P<0.05]及C反应蛋白(CRP)浓度[(7.34±6.78)mmo/L vs.(2.97±2.56)mmo/L,t=11.894,P<0.05]较高,差异均有统计学意义,且吸烟史(52.07%vs.35.19%,χ~2=60.792,P<0.0)、糖尿病(30.05%vs.10.19%,χ~2=49.463,P<0.05)、原发性高血压(高血压)(53.63%vs.29.13%,χ~2=49.489,P<0.05)及冠状动脉粥样硬化性心脏病(冠心病)家族史(33.94%vs.10.92%,χ~2=61.408,P<0.05)的比例较高,差异均有统计学意义。Logistic回归分析显示,ABO血型与急性心肌梗死相关,非O血型患急性心肌梗死的风险明显高于O血型(OR=1.635,95%CI:1.376~1.976,P<0.05),对性别、吸烟、高血压、糖尿病、冠心病家族史、胆固醇浓度等急性心肌梗死危险因素进行校正后,该风险仍然存在(OR=1.312,95%CI:0.987~1.895,P<0.05)。结论 ABO血型与急性心肌梗死的发生存在相关性,非O型血较O型血更易发生急性心肌梗死。Objectives To analyze the correlation between ABO blood group and risk of acute myocardial infarction in human. Methods The study was carried out in observed group consisting of 386 cases with acute myocardial in- farction and healthy control group with 412 cases of the same period healthy subjects outpatients. The biochemical index of ABO blood group, fasting blood-glucose （FBG） and blood lipids were mensurated , respectively. Correlation between ABO blood group and acute myocardial infarction was analyzed by Logistic multiple regression analysis. Results Compared to control group, observed group had higher concentrations of low density lipoprotein cholesterin [ （ 2.91 ± 1. 12） mmo/L vs. （ 2.55± 1.03 ） mmo/L, t=4.730, P〈0.05 ] , fasting blood-glucose （ FBG ） [ （ 6.76±4.85 ） mmo/L vs. （ 4.53±1.26 ） mmo/L, t=8.761, P〈0.05 ] and C reactive protein （CRP） [ （ 7.34±6.78 ） mmo/L vs. （2.97±2.56） mmo/L, t=11.894, P〈0.05], there were statistical differences between the two groups; as well as higher proportion of smoking （52.07% vs. 35.19%, χ2=60.792, P〈0.0）, history of diabetes （30.05% vs. 10.19%, χ2=49.463, P〈0.05 ）, history of hypertension （53.63% vs. 29.13% , χ2=49.489, P〈0.05） and family history of coronary heart disease （33.94% vs. 10.92% ,χ2=61.408, P〈0.05 ）, there were statistical differences between the two groups. Logistic analysis indicated that ABO blood groups associated with acute myocardial infarction. Compared with O blood group, the non-O blood group individuals had a higher risk of acute myocardial infarction （OR=1.635, 95%CI： 1.376-1.976, P〈0.05） , this result remained after adiustment for the conventional cardiovascular risk factors such as gender, smoking, hypertension, diabetes, history of coronary heart disease and serum cholesterol concentration （OR=1.312, 95%CI： 0.987-1.895, P〈0.05）. Conclusions ABO blood group are closely related to the occurrence of acute myocardial infarction. Non-O blood group of people

关 键 词：心肌梗死 ABO血型 相关性 

分 类 号：R542.22[医药卫生—心血管疾病]