先天性心脏病患儿血浆肾上腺髓质素与肺动脉高压的关系  

Correlation between adrenomedullin and pulmonary artery hypertension in patients with congenital heart disease

作　　者：秦静廷[1] 阳明玉[1] 王丹[1] 宋晓丹[1] 王昕[1] 王海永[2] 

机构地区：[1]桂林医学院附属医院儿科,广西桂林541001 [2]桂林医学院附属医院心胸外科,广西桂林541001

出　　处：《岭南心血管病杂志》2017年第2期191-193,共3页South China Journal of Cardiovascular Diseases

基　　金：广西壮族自治区教育厅课题资助项目(项目编号:LX2014261)

摘　　要：目的探讨肾上腺髓质素(adrenomedullin,ADM)与小儿先天性心脏病(先心病)并发肺动脉高压(脉高压)的关系。方法应用放射免疫分析法(RIA)检测50例先心病患儿及20名正常对照组血浆ADM浓度。50例先心病患儿经用彩色多普勒超声心动图估测肺动脉压力,分为4组:无肺高压组16例、轻度肺高压组14例、中度肺高压组12、重度肺高压组8例。结果先心病无肺高压组ADM浓度稍高于正常对照组,但差异无统计学意义(P>0.05)。先心病患儿血浆ADM浓度随着肺动脉压升高而明显升高,差异有统计学意义(P<0.01)。结论先心病并发肺动脉高压患儿血浆ADM浓度升高,检测ADM对先心病并发肺高压具有一定的诊断价值,可作为先心病并发肺动脉高压评价的一个客观指标。Objectives To investigate the correlation between adrenomedullin （ADM） and pulmonary artery hypertension （PAH） in patients with congenital heart disease （CHD）. Methods Radioimmunoassay （RIA） was used to determine the concentration of ADM in 50 patients with CHD （CHD group） and 20 healthy children （control group）. The 50 CHD patients were divided into 4 groups after the estimation of the pulmonary arterial pressure by Color Doppler cardiogram： non-PAH group （16 cases）, mild PAH group （14 cases） , moderate degree PAH （12 cases） and severe PAH group （8 cases）. Results Concentration of ADM in non-PAH group was higher than that of control group, and the difference was statistically significant （P〉0.05）. Concentrations of ADM in patients with CHD patients increased obviously with the increasing of pulmonary arterial pressure, and the difference was statistically significant （P〈0.01）. Conclusions Concentration of ADM increases in patients with CHD, and it correlates with PAH. So, the detection of concentration of ADM has diagnostic values in patients with CHD combined with PAH, and it can be used as an objective indicator to diagnose CHD combined with PAH.

关 键 词：心脏缺损 先天性 肾上腺髓质素 肺动脉高压 

分 类 号：R541.7[医药卫生—心血管疾病]