酸浆苦素抗日本血吸虫作用研究  

Antischistosomal Activity of Physalins against Schistosomajaponicum

作　　者：张苏[1] 李冀[1] 杨世林[2] 李笑然[2] 许琼明[2] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]苏州大学药学院,江苏苏州215123

出　　处：《中医药学报》2017年第2期25-29,共5页Acta Chinese Medicine and Pharmacology

摘　　要：目的:考察酸浆苦素(Physalins)对日本血吸虫病的治疗效果。方法:将ICR小鼠随机分为11组,在感染后1天、14天、35天后采用灌胃法给予不同剂量(60,30,15 mg/kg)酸浆苦素治疗,感染后第49天处死小鼠,观察不同给药组小鼠的总虫数、雌虫数、体质量、脾指数及肝脏肉芽肿变化。结果:与对照组相比,在感染日本血吸虫1天给予低剂量酸浆苦素及35天给予高、中、低剂量酸浆苦素能明显降低小鼠体内总虫数及雌虫数(P<0.01)。在感染1天给予酸浆苦素治疗能明显增加小鼠体质量,其中1天中剂量给药组小鼠体质量和脾指数明显降低(P<0.01)。并且,在感染1天给予高、中、低剂量酸浆苦素治疗及35天给予低剂量酸浆苦素能明显降低小鼠肝脏中虫卵肉芽肿的直径,与对照组相比有显著差异(P<0.01)。结论:酸浆苦素对感染早期的日本血吸虫病有一定的治疗效果。Objective ： To investigate the effect of Physalins on schistosomiasis. Methods ICR mice were randomly divided into eleven groups. We treated 1 - day - old, 14 - day - old and 35 - day - old Schistosoma japonicum infected mice with 60, 30, 15 mg/kg Physalins, respectively, with orally once a day for rive consecutive days. The mice were sacri- riced on the 49＇8 day of post - infection. Observe the changes of the number of total worms, the number of female worms, body weight, spleen index and granuloma of different groups. Results：Administration of 15 mg/kg Physalins to the 1st day or administration of 60, 30 and 15 mg/kg Physalins to the 35th day post -infected mice could significantly reduce the total worms and female worms compared with those in the control group （ P 〈 0.01 ）. Physalins for 1 - day - old Schistosoma japonicam infected mice could significantly improve the body weight and reduce the spleen index （P 〈 0. 01 ）. In addition, administration of 60, 30 and 15 mg/kg Physalins to the 1st day or administration of 15 mg/kg Phys- alins to the 35th day post - infected mice could significantly reduce the diameter of granuloma. Conclusion ： Physalins has a therapeutic effect on early infectious schistosomiasis.

关 键 词：酸浆苦素 日本血吸虫 总虫数 雌虫数 肉芽肿 杀虫效果 

分 类 号：R285.5[医药卫生—中药学]