NT-proBNP和HCY对原发性高血压患者合并左心室肥厚的预测价值  

Predictive value of NT-proBNP and HCY in patients with essential hypertension complicating left ventricular hypertrophy

作　　者：聂亚红[1] 张蓉[1] 张磊[1] 牟晓峰[1] 

机构地区：[1]青岛大学附属中心医院检验科,山东青岛266042

出　　处：《国际检验医学杂志》2017年第9期1160-1162,共3页International Journal of Laboratory Medicine

基　　金：山东省青岛市卫生和计划生育委员会立项课题(2011-WSZD075)

摘　　要：目的探讨原发性高血压(EH)合并左心室肥厚(LVH)患者血N-末端氨基末端脑钠肽前体(NT-proBNP)和同型半胱氨酸(HCY)的水平及临床意义。方法 150例原发性高血压患者根据心脏超声结果分为高血压LVH(EH-LVH)组和单纯EH组。另取健康体检者100例作为对照组,比较三组人员血NT-proBNP和HCY水平,并进行相关性分析。结果 EH-LVH组血NT-proBNP和HCY水平均明显高于EH组和对照组,EH组显著高于对照组,差异具有统计学意义(P<0.05)。血NTproBNP和HCY水平与左室重量质量指数(LVMI)呈显著正相关,与二尖瓣口流速E/A呈负相关(P<0.05)。结论 NT-proBNP和HCY水平可作为EH发生、发展的监测指标,并对其合并LVH具有一定的预测价值。Objective To explore the levels of blood N-terminal pro-brain nat r iuret ic pept ide（NT-proBNP） and homocysteine （HCY） and their clinical significance in the patients with essential hypertension （EH） complicating left ventricular hypertrophy （LVH）. Methods One hundred and fifty cases of HE were divided into the EH-LVH group and simple EH group according to the results of cardiac ultrasound. One hundred individuals undergoing physical examination were selected as the control group. The lev-els of blood NT-proBNP and HCY were compared among three groups and the correlation analysis were analyzed with LV was per-formed. Results The levels of blood NT-proBNP and HCY in the EH-LVH group were obviously higher than those in the EH group and control group, the EH group was significantly higher than the control group, the difference was statistically significant （P〈0 . 05）. The levels of blood NT-proBNP and HCY had significantly positive correlation with left ventricular mass index（LV- MI） , while negative correlation with mitral flow velocity E/A（P〈0. 05）. Conclusion The NT -pro BNP and HCY levels can be used as the indicators for monitoring the development and progress of EH and has some predictive value for its complicating LVH.

关 键 词：原发性高血压 左心室肥厚 N-末端氨基末端脑钠肽前体 同型半胱氨酸 

分 类 号：R544.11[医药卫生—心血管疾病]