联合检测肌钙蛋白T及肌红蛋白和NT-ProBNP在心肌梗死诊断中的临床研究  

Clinical study of combined detection of troponin T,myoglobin and NT-ProBNP in diagnosis of myocardia linfarction

作　　者：沈菲[1] 张成芳[1] 赵娟[1] 陈广新[1] 李辉[1] 廖小明[1] 

机构地区：[1]广东省广州市花都区人民医院,510800

出　　处：《国际检验医学杂志》2017年第9期1220-1221,1224,共3页International Journal of Laboratory Medicine

摘　　要：目的观察联合检测肌钙蛋白(cTnT)、肌红蛋白(Myo)及血浆氨基末端B型利钠肽前体(NT-proBNP)在心肌梗死(MI)诊断中的临床应用。方法选择2012年1月至2015年12月以急性胸痛为主诉入院进行检查治疗的患者共计913例,根据最终诊断结果将患者分为急性MI组和非急性MI组。所有患者来诊后检测其cTnT、Myo及NT-proBNP水平。观察2组患者cTnT、Myo、NT-proBNP的差异,观察上述3项指标单独检测、二联检测和三联检测诊断急性MI的灵敏度和特异度。结果急性MI组患者cTnT、Myo、NT-proBNP水平均明显高于非急性MI组,差异有统计学意义(P<0.05)。二联检验的灵敏度和特异度高于cTnT、Myo、NT-proBNP单独检验,而三联检验的灵敏度为95.18%,特异度为89.86%,明显高于单独检验及二联检验。结论 cTnT、Myo、NT-proBNP的联合检验在MI诊断中具有重要意义,能够提高MI诊断的特异度和灵敏度,为临床治疗提供可靠依据。Objective To observe the clinical application of combined detection of troponin T(cTnT),myoglobin(Myo)and NTProBNP in the diagnosis of myocardial infarction(MI).Methods A total of 913 cases of acute chest pain complaints to our hospital for examination and treatment from January 2012 to December 2015 were selected and divided into the acute MI group and non-acute MI group according to the final diagnostic results.The cTnT,Myo and NT proBNP levels were detected in all subjects.The differences of cTnT,Myo and NT-proBNP levels were observed in the two groups.The sensitivity and specificity of single indicator detection,2-indicator combined detection and 3-indicator combined detection for diagnosing MI were observed.Results The levels of cTnT,Myo and NT-proBNP in the acute MI group were significantly higher than those in the non-acute MI group,the difference was statistically significant(P<0.05).The sensitivity and specificity of the two-indicator combined detection were higher than those of cTnT,Myo and NT-proBNP single detection,the sensitivity and specificity of the 3-indicator combined detection were95.18% and 89.86%respectively,which were significantly higher than those of the single indicator test and the two-indicator combined detection.Conclusion The combined examination of cTnT,Myo and NT-proBNP has important significance in the diagnosis of MI,can improve the specificity and sensitivity of MI diagnosis and provides a reliable basis for clinical treatment.

关 键 词：肌钙蛋白T 肌红蛋白 氨基末端B型利钠肽前体 心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]