生物样品的色谱-质谱定性确认指标  

Confirming Indicators of Qualitative Results by Chromatography-mass Spectrometry in Biological Samples

作　　者：刘少丹 张大明[2] 张炜[2] 张文芳[2] LIU Shao-dan ZHANG Da-ming ZHANG Wei ZHANG Wen-fang(School of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, China Forensic Medical Identification Center of Beijing Municipal Public Security Bureau, Beijing 100192, China)

机构地区：[1]山西医科大学法医学院,山西太原030001 [2]北京市公安局法医鉴定中心,北京100192

出　　处：《法医学杂志》2017年第2期181-188,共8页Journal of Forensic Medicine

摘　　要：由于复杂基质的存在,生物样品中毒物的色谱-质谱定性确认指标与非生物样品有所不同。即使同为生物样品,定性确认指标也会因应用领域的不同而不尽相同。本文综述了法医毒物分析及其他应用领域生物样品中待测物的色谱-质谱定性确认指标的异同,这些确认指标主要包括保留时间、相对保留时间、信噪比、特征离子、特征离子的相对丰度、母离子-子离子对和离子对丰度比等。Because of the exist of complex matrix, the confirming indicators of qualitative results for toxic substances in biological samples by chromatography-mass spectrometry are different from that in non-biological samples. Even in biological samples, the confirming indicators are different in various ap-plication areas. This paper reviews the similarities and differences of confirming indicators for the analyte in biological samples by chromatographymass spectrometry in the field of forensic toxicological analysis and other application areas. These confirming indicators include retention time （RT）, relative re-tention time （RRT）？ signal to noise （S/N）, characteristic ions, relative abundance of characteristic ions, parent ion-daughter ion pair and abundance ratio of ion pair, etc.

关 键 词：法医毒理学 色谱法 质谱分析法 综述 质量控制 定性研究 确认指标 生物样品 

分 类 号：R284.1[医药卫生—中药学]