铜粉催化叠氮与端炔1,3-偶极环加成反应研究  

1,3-Dipolar cycloaddition of azides and alkynes catalyzed by copper powder

作　　者：李冠琼[1] 林秋汉[2] Li Guanqiong Lin Qiuhan(Patent Examination Cooperation Center of the Patent Office,State Intellectual Property Office of the PRC , Guangzhou 510530 , China School of Chemical Engineering, Nanjing University of Science and Technology,Nanjing 210094, China)

机构地区：[1]国家知识产权局专利局专利审查协作广东中心,广东广州510530 [2]南京理工大学化工学院,江苏南京210094

出　　处：《南京理工大学学报》2017年第2期239-244,共6页Journal of Nanjing University of Science and Technology

基　　金：国家自然科学基金(20772011)

摘　　要：该文探讨了普通铜粉高效催化的叠氮化物与端炔的1,3-偶极环加成反应。研究结果表明,以铜粉为催化剂,盐酸三乙胺(Et3N·HCl)为助催化剂,体积比为1∶1的水/叔丁醇(H2O/t-Bu OH)为溶剂,将叠氮化物与端炔于室温常压下反应2 h,高收率合成1,4-二取代-1,2,3-三唑化合物,收率可达93.05%。该方法所用催化剂廉价易得,且用量少,反应条件温和,耗时短,收率高,后处理操作简单。The 1,3-dipolar cycloaddition of azides and alkynes efficiently catalyzed by copper powder is studied. The reaction is efficiently performed in the presence of copper powder as the catalyst and the triethylamine hydrochloride （ Et3 N · HCl） as the promoter in the water/t-butyl alcohol （ H2O/ t-BuOH） （volume ratio 1：1） under the room temperature and the normal pressure for 2 h,and the yield ratio of the 1,4-disubstituted 1,2 ,3-triazoles is up to 93.05%. The procedure is characterized by the lower amount of the inexpensive catalyst, the mild reaction condition, the little time-consuming, the high productivity and the easy operation.

关 键 词：1 3-偶极环加成反应 铜粉 盐酸三乙胺 1 4-二取代-1 2 3-三唑 

分 类 号：O626.26[理学—有机化学]