甘油三酯葡萄糖乘积指数与心血管疾病危险因素聚集关系的研究  

Study on the relationship between triglyceride-glucose (TyG) index and the clustering of risk factors for cardiovascular disease

作　　者：宋健[1] 陈雪[1] 张杰[1] 吴学森[1] SONG Jian CHEN Xue ZHANG Jie WU Xue-sen.(Department of Preventive Medicine, Bengbu Medical College, Bengbu 233000, Chin)

机构地区：[1]蚌埠医学院预防医学系,安徽蚌埠233000

出　　处：《中华疾病控制杂志》2017年第4期362-365,374,共5页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81373100)

摘　　要：目的探讨成年人甘油三酯葡萄糖乘积(triglyceride-glucose index,TyG)指数与心血管疾病危险因素聚集的关系。方法采用随机抽样的方法,调查安徽省蚌埠市龙子湖区居民,共1 777名,调查内容主要包括问卷调查,身体指标测量和实验室检查。将TyG指数按四分位数分组,使用Logistic多因素回归分析TyG指数与心血管疾病危险因素聚集的关系。通过受试者工作特征(receiver operator characteristic curve,ROC)曲线分析,计算TyG指数判断心血管疾病危险因素聚集的临界值及作用大小,并与其余指标进行比较。结果调查人群男性748人(42.09%),女性1 029人(57.91%)。平均年龄为(60.82±11.24)岁。Spearman相关分析表明TyG指数与心血管疾病危险因素均存在相关性(均有P<0.001)。Logistic多因素分析显示,TyG指数是心血管疾病危险因素聚集的危险因素(OR=2.930,95%CI:2.625~3.272)。TyG指数为8.78时,判断心血管疾病危险因素聚集的约登指数最大。其ROC曲线下面积与空腹血糖、甘油三酯、身高体重指数(body mass index,BMI)的相比差异均有统计学意义(均有P<0.05),而与腰围身高比(waist-to-height ratio,WHtR)的差异无统计学意义(Z=0.117,P=0.907)。结论TyG指数与心血管危险因素聚集密切相关,可做为识别心血管疾病危险因素聚集的简单工具。Objective To explore the relationship between triglyceride-glucose（ TyG） index and clustering of cardiovascular risk factors in adolescents. Methods A total of 1 777 residents from Longzihu area in Bengbu,Anhui Province were selected by random sampling. Questionnaires,physical examination and laboratory measurements were used to collect general and clinical information. TyG index was grouped by quartiles. Logistic regression analysis was performed to analyze the relationship between TyG index and cardiovascular risk factors clustering. Using ROC curve analysis,the cutoff value and clinical significance of cardiovascular risk factors clustering prediction by TyG index were calculated for comparison with other indicators. Results The survey included total 748 males（ 42. 09%） and 1 029 females（ 57. 91%）with the average age of（ 60. 82 ± 11. 24） years. Spearman correlation analysis showed that TyG index were significantly correlated with cardiovascular disease risk factors（ all P〈0. 001）. Indeed,multivariate Logistic analysis showed that TyG index was a risk factor for cardiovascular disease risk factors clustering（ OR = 2. 930,95% CI： 2. 625-3. 272）. When the TyG index was 8. 78,the Youden index of cardiovascular disease risk factors clustering determination by TyG index was the maximum. The area under the receiver operator characteristic curve（ ROC） curve of TyG index was significantly different from that of fasting blood glucose,triglycerides and body mass index（ BMI）（ all P〈0. 05）. However,no significant difference was observed when compared with waist-to-height ratio（ WHtR）（ Z = 0. 117,P = 0. 907）. Conclusions There is a significant correlation between TyG index and clustering of cardiovascular risk factors,suggesting that TyG index may be applied as a simple marker for identifying adolescents with clustering of cardiovascular risk factors.

关 键 词：甘油三酯类 胰岛素 心血管疾病 危险因素 

分 类 号：R347.8[医药卫生—基础医学] R181.2