外周血5-羟色胺及5-羟色氨酸水平与驾驶员事故倾向性关系研究  

Study on the relationship between 5-HT,5-HTP levels in peripheral blood and drivers' accident proneness

作　　者：邓宇[1] 杨家丽[2] 王晓敏[3] 黄开勇[1] 曾西[1] 杨骏[1] 杨莉[1] DENG Yu YANG Jia-li WANG Xiao-min HUANG Kai-yong ZENG Xi YANG Jun YANG Li(Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China Department of Public Health Surveillance and Evaluation, Beihai Center for Disease Control and Prevention, Beihai 536000, China Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China)

机构地区：[1]广西医科大学公共卫生学院职业卫生与环境卫生学教研室,广西南宁530021 [2]北海市疾病预防控制中心公共卫生监测评价科,广西北海536000 [3]广西医科大学公共卫生学院流行病与卫生统计学教研室,广西南宁530021

出　　处：《中华疾病控制杂志》2017年第4期395-398,共4页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81560528);广西高校科学技术研究项目(KY2015YB064);广西高校中青年教师基础能力提升项目(KY2016YB088)

摘　　要：目的探讨外周血5-羟色胺(5-hydroxytryptamine,5-HT)及5-羟色氨酸(5-hydroxytryptophan,5-HTP)水平与驾驶员事故倾向性的关系。方法采用病例对照研究方法,选取2008年1月~2012年12月中发生三次及三次以上同等责任交通事故的机动车驾驶员纳入病例组,按照同性别、同种驾驶车型以及年龄和驾龄相差不到2岁,同一时期且未发生过道路交通伤害(road traffic injuries,RTIs)的驾驶员作为对照组。结果病例组体内5-HT及5-HTP水平均低于对照组(均有P<0.05)。多因素Logistic回归分析结果显示,5-HT低水平及5-HTP低水平与机动车驾驶员事故倾向性有关(均有P<0.05)。结论驾驶员5-HT水平和5-HTP水平与其事故倾向性可能有关;5-HT和5-HTP水平高是驾驶员事故倾向性的保护因素。Objective To investigate the relationship between 5-hydroxytryptophan（ 5HT）,5-hydroxytryptophan（ 5-HTP） level in peripheral blood and the drivers＇ accident proneness. Methods A case-control study was applied to this study. The motor vehicle drivers who had 3 or more times the same responsibility of road traffic accidents from January 2008 to December 2012 were selected as the cases,and other drivers who had not happened road traffic injuries during the same period with similar gender,vehicle type,age and driving years less than 2 years old as the control group. Results The levels of 5-HT and 5-HTP in the case group were lower than those in the control group（ all P〈0. 05）. Multivariate logistic regression analysis showed that the low level of 5-HT and the low level of 5-HTP were related to motor vehicle drivers＇ accident proneness（ all P〈0. 05）. Conclusions The driver accident proneness is related to the level of 5-HT and 5-HTP.5-HT and 5-HTP levels were protective factors of drivers＇ accident proneness.

关 键 词：汽车驾驶 事故倾向 5-羟色氨酸 

分 类 号：R181.1[医药卫生—流行病学]