长期有氧运动上调老年大鼠骨组织中Wnt/β-catenin通路  

Chronic Aerobic Exercise Training Activates Skeletal Wnt/β-catenin Pathway in Aged Rats

作　　者：王兵[1] 段富贵[2] WANG Bing DU AN Fu-gui(School of Physical Education,Xi＇an Technological University,Xi＇an 710032,China Physical Education Department of Jiaozuo Teachers College, Jiaozuo Henan 454000 , China)

机构地区：[1]西安工业大学体育学院,西安710032 [2]焦作师范高等专科学校体育学院,河南焦作454000

出　　处：《西南师范大学学报（自然科学版）》2017年第4期132-136,共5页Journal of Southwest China Normal University(Natural Science Edition)

摘　　要：为探讨长期有氧运动对年老大鼠骨组织中Wnt/β-catenin通路的影响,将实验分为:青年组(Young),年老大鼠组(Old),年老大鼠+运动组(Old+EX),运动为跑台运动,持续12周.结果发现:与青年组大鼠相比,老年组大鼠的股骨和L2-5段椎骨的骨密度(BMD)明显下降,股骨的极限载荷和刚度明显降低;年老大鼠经过长期有氧运动后,股骨和L2-5段椎骨的骨密度、股骨的极限载荷和刚度都得到明显增加.实时定量PCR结果显示老年组大鼠的股骨中Wnt1,Wnt3a,Lrp5,Axin2和ctnnb1的mRNA水平明显降低,但长期进行有氧运动的老年组大鼠股骨中Wnt1,Wnt3a,Lrp5,Axin2和ctnnb1的mRNA水平得到明显增加.可以认为长期有氧运动可上调老年大鼠骨组织中Wnt/β-catenin通路,有助于减轻或延缓年老大鼠的骨质丢失.The aim of this paper is to investigate the role of Wnt/｜3 -catenin pathway in chronic aerobic exer-cise-induced attenuation of osteoporosis in aged rats. Male rats have randomly been divided into three groups as follows： 1） sedentary young group （Young, as control group）; 2） sedentary old group （Old）; and 3） exercised-trained old group （Old ＋ EX）. Exercise for the treadmill exercise for 12 weeks. In this work, chronic aerobic exercise training in aged rats prevented the reduction of bone mineral density of fe-murs and L 2-5 vertebra and preserved mechanical strength including ultimate load and stiffness in femurs. Interestingly, chronic aerobic exercise in aged rats unregulated mRNA expression of Wntl, Wnt3a , Lrp5, Axin2, and ctnnbl in femurs. It is concluded that chronic aerobic exercise training ameliorated senior oste-oporosis in aged rats via activating Wnt/｜3 -catenin pathway, at least in part.

关 键 词：有氧运动 老年大鼠 WNT/Β-CATENIN通路 骨质疏松 

分 类 号：G804.2[文化科学—运动人体科学]