促红细胞生成素对心肌缺血再灌注损伤的保护作用  

Protective effects of erythropoietin on myocardial ischemia reperfusion injury in rats

作　　者：国科 刘达兴[1] 容松[1] GUO Ke LIU Daxing RONG Song(Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Zunyi Medical College,Zurvyi, Guizhou 563003 , Chin)

机构地区：[1]遵义医学院附属医院胸心血管外科,贵州遵义563003

出　　处：《安徽医药》2017年第3期391-394,共4页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金(81260056);贵州省卫计委科技基金(gzwjkj 2014-1-074)

摘　　要：促红细胞生成素(erythropoietin,EPO)是一种酸性含糖量多的蛋白类激素,目前在临床上主要用于治疗各种疾病导致的贫血。但此前有研究发现,EPO还具有显著的心肌保护作用,这种心肌保护效应主要体现在各种组织器官发生缺血再灌注损伤(ischemia reperfusion injury,IRI)时。现就EPO对心肌的保护作用的可能信号转导机制及目前国内外研究进展,作一综述。Erythropoietin （EPO） ,as one kind of glycoprotein,is currently in clinic mianly used to treat anemia caused by various disea-ses. Whereas the study found that EPO also has obviously myocardia protective effect,and this kind of cardio-protective effect is mainly happened in a variety of tissues and organs,when they were faced with ischemia and reperfusion injury. New study mainly concentrates on the function of myocardial-protection. This article summarizes the cardio-protection effects of EPO during ischemia and reperfusion injury about its related possible mechanisms and signal transduction taking part in regulation.

关 键 词：促红细胞生成素 再灌注损伤 心肌缺血 

分 类 号：R96[医药卫生—药理学]