初诊2型糖尿病病人脂蛋白(a)与胰岛素抵抗的相关性分析  

Association of lipoprotein(a) and insulin resistance in newly diagnosed type 2 diabetes patients

作　　者：吕齐欢[1] 马维青[1] 叶启宝[1] 何媛媛[1] 陈丽[1] 

机构地区：[1]合肥市第一人民医院南区内分泌科,安徽合肥230061

出　　处：《安徽医药》2017年第3期504-507,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨初诊2型糖尿病(T2DM)病人血清脂蛋白(a)[Lp(a)]与胰岛素抵抗的关系。方法检测95例初诊T2DM病人(T2DM组)和40例健康体检者(NC组)血清生化指标,计算胰岛素抵抗指数(HOMA-IR)。比较两组间各指标的差异。结果 T2DM组Lp(a)为(1.78±0.35)低于NC组的(1.85±0.57)(t=2.574,P=0.020)。相关分析显示:Lp(a)与胰岛素、HOMA-IR、三酰甘油呈负相关(P<0.05))。线性回归分析显示:Lp(a)在NC组和T2DM组都与HOMA-IR相关(β=-0.003,P=0.001;β=-0.001,P=0.001)。结论 Lp(a)在T2DM人群中水平低于正常人群,在两组中都与胰岛素抵抗呈独立的负相关性。Objective To investigate the association of serum lipoprotein(a) [Lp(a) ] and insulin resistance in newly diagnosed type2 diabetes patients. Methods Ninety-five newly diagnosed type 2 diabetes patients(T2DM group) and 40 healthy people(NC group)were enrolled. The serum biochemical indices were detected. Insulin resistance index(HOMA-IR) was calculated. We compared the data statistically of the two groups. Results The level of serum Lp(a) of T2DM group was lower than NC group [(1. 78 ± 0. 35) vs(1. 85 ± 0. 57); t = 2. 574,P = 0. 020]. Pearson correlation analysis showed that Lp(a) was negatively correlated with INS,HOMA-IR and TG. Linear regression analysis showed that in both T2DM group and NC group serum Lp(a) was correlated with HOMA-IR(β =-0. 003,P = 0. 001; β =-0. 001,P = 0. 001). Conclusion The level of Lp(a) is lower in T2DM group than in NC group and it is independently and negatively associated with insulin resistance.

关 键 词：脂蛋白A 糖尿病 2型 胰岛素抗药性 因果律 

分 类 号：R587.1[医药卫生—内分泌]