神经外科病人预防癫痫发生的用药分析  

Analysis of drug use for neurosurgical patients' prevention of epilepsy

作　　者：张秋菊[1] 贾茹[1] 王亚娟[1] 邓宁[1] 熊建功[1] 朱秀琪[1] 

机构地区：[1]宁夏医科大学总医院心脑血管病医院药剂科,宁夏回族自治区银川750002

出　　处：《安徽医药》2017年第3期563-565,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的分析某医院收治的颅脑疾病病人预防癫痫发生的具体用药情况。方法对某医院神经外科的出院病例进行回顾性调查,分析病人疾病种类、是否手术及具体手术类别,预防癫痫发作的药物使用情况。结果所调查146例使用抗癫痫药物的病例中,以脑出血病人预防用抗癫痫药为多数;平均住院天数12.6 d;手术病例96例,平均手术时间是3.18 h;非手术病人50例。手术病人大多术后即刻或者术前1~3 d预防使用丙戊酸钠,住院期间预防用丙戊酸钠后无癫痫发作,术后无预防的癫痫发生率为6.8%。结论该医院颅脑疾病病人预防癫痫发作以使用抗癫痫药丙戊酸钠为主,手术病人术后即刻或者术前预防用抗癫痫药术后癫痫的发生率明显降低。Objective To investigate the prophylactic medication status for epileptic seizure among patients with craniocerebral diseases admitted to neurosurgery department of our hospital. Methods Retrospective investigation was performed on patients discharged from neurosurgery department of our hospital,for the analysis of disease type,whether surgery was performed and the specific surgery type,and the prophylactic medications for epileptic seizure. Results Among the 146 patients receiving antiepileptics,the mean duration of hospitalization was 12. 6d,96 patients underwent surgery,with the mean surgery duration 3. 18 h,and 50 patients did not undergo surgery. The majority of the patients undergoing surgery received prophylactic treatment with sodium valproate immediately after surgery or 1-3 days prior to surgery,with prophylactic treatment with sodium valproate,none of the patients experienced epileptic seizure during hospitalization,and the incidence of postoperative epileptic seizure without prophylactic treatment was 6. 8%,the prophylatic antiepileptics were primarily for the treatment of cerebral hemorrhage,and none of the patients experienced epileptic seizure with prophylactic medication. Conclusions For the prevention of epileptic seizure,the patients with craniocerebral diseases primarily used the antiepileptic sodium valproate,and the use of prophylactic antiepileptics immediately after or prior to surgery significantly reduced the incidence of postoperative epileptic seizure.

关 键 词：癫痫/预防和控制 药物处方 脑损伤 脑肿瘤 脑血管障碍 

分 类 号：R651[医药卫生—外科学]