Nrf2抗氧化应激保护内皮细胞损伤的研究进展  

Research Progress of Nrf2 Regulate Oxidative Stress in Vascular Endothelial Cells

作　　者：李全[1] 张源[1] 梁跃伟 阮锐[1] 周如丹[1] 赵学凌[1] 

机构地区：[1]昆明医科大学第一附属医院

出　　处：《昆明理工大学学报（自然科学版）》2017年第2期77-81,共5页Journal of Kunming University of Science and Technology(Natural Science)

基　　金：国家自然科学基金项目(81560366);云南省医疗单位内设机构科研项目(2016NS021)

摘　　要：核因子E2相关因子2（Nuclear factor E2 related factor 2,Nrf2）是氧化应激高敏感性转录因子,氧化应激导致Nrf2与锌指样环氧氯丙烷相关蛋白1（Kelch-like ECH-associated protein 1,Keap1）分离进入细胞核结合抗氧化元件（Antioxidant Response Element,ARE）促进多种抗氧化基因和II相解毒酶的转录表达.转录因子Nrf2是细胞抗氧化还原的中枢调节者,在氧化应激反应中起关键作用.Nrf2驱动自由基阳离子通道是重要的内源性稳态机制,在抗炎症、抗凋亡、抗肿瘤、抗动脉粥样硬化、神经保护等方面起着重要的作用.对Nrf2/ARE信号通路和Nrf2保护氧化应激诱导内皮细胞损伤的最新研究作一综述.Nuclear factor E2 related factor 2（ Nrf2） is a highly sensitive transcription factor of oxidative stress,which leads to the isolation of Nrf2 and Keap1,then Nrf2 entering into the nucleus with ARE to promote the transcription of several antioxidant genes and II phase detoxification enzymes. Transcription factor Nrf2 is a key factor in the oxidative stress response,and the central regulator of cell antioxidant reduction. Nrf2 drive free radical cation channel is an important endogenous homeostatic mechanism,which plays a significant role in anti-inflammatory,anti apoptosis,anti tumor,anti atherosclerosis,and neural protection. The recent studies on the Nrf2/ARE signaling pathway and Nrf2 protection of endothelial cell damage induced by oxidative stress are reviewed and summarized in this paper.

关 键 词：Nrf2/ARE信号通路 核转录因子Nrf2 氧化应激 内皮细胞损伤 

分 类 号：R322.12[医药卫生—人体解剖和组织胚胎学]