终末期肾病患者血管钙化风险与维生素K_2摄入关系的前瞻性研究  

Relationship between risk of angiosteosis and vitamin K_2 intake in patients with end-stage renal disease: a prospective clinical study

作　　者：刘倩[1] 黄雯静[1] 舒婷婷[1] 黄向阳[1] 

机构地区：[1]柳州市工人医院肾内科,广西柳州545005

出　　处：《海南医学》2017年第7期1053-1055,共3页Hainan Medical Journal

基　　金：广西壮族自治区卫生厅科研课题(编号:Z2014673);广西柳州市科学研究与技术开发计划课题(编号:2014J030411);2014年广西肾脏病临床重点专科建设项目资助

摘　　要：目的探讨维生素K_2的摄入对降低血透患者血管钙化风险的效果。方法根据摄入的维生素K_2剂量不同,将2014年1月至2016年9月在我院住院的维持性血液透析的患者75例分为360μg、720μg、1 080μg三组,每组25例。采用维生素K_2治疗8周,观察各组患者治疗前后生长停滞特异性蛋白6(Gas6)的表达,并探讨其与维生素K_2摄入量是否存在浓度相关性。结果 1 080μg组患者治疗后Gas6下降率为42.8%,明显高于360μg组的16.4%及720μg组的28.4%,差异均具有显著统计学意义(P<0.01);血液透析患者血液中Gas6水平随着维生素K_2摄入剂量的增高,呈现逐渐下降趋势,具有显著相关性(r=-0.24,P<0.01)。结论维生素K_2的摄入可有效降低血液透析患者血管钙化的风险。Objective To investigate the effect of vitamin K2 intake on reducing the risk of angiosteosis in hemodialysis patients. Methods According to the intake of vitamin K2, 75 patients with hemodialysis in Liuzhou Worker＇s Hospital from January 2014 to September 2016 were randomly divided into three groups： 360 μg group, 720 μg group and 1 080 μg group, with 25 patients in each group. All the patients were treated with vitamin K2 for 8 weeks. Expression of growth arrest-specific protein 6（Gas6） were observed before and after treatment among three groups, and Its correlation with vitamin K2 concentration were statistically analyzed. Results Gas6 decline rate of 1 080 μg group（42.8%） was significantly higher than that of 360 μg group（16.4%） and 720 μg group（28.4%）, P〈0.01. Spearman correlation analysis showed that there was a negative correlation between the dose of vitamin K2 intake and the change of Gas6 level（r=-0.24, P〈0.01）. Conclusion Vitamin K2 intake can effectively reduce the risk of vascular calcification in patients with hemodialysis.

关 键 词：维生素K2 生长停滞特异性蛋白6 血管钙化 终末期肾病 血液透析 

分 类 号：R692[医药卫生—泌尿科学]