血小板源性生长因子B及受体α mRNA在复发性尖锐湿疣皮损中的表达与意义  

Expression and significance of platelet derived growth factor B and its receptorsαin skin lesions of recurrent condyloma acuminatum

作　　者：王军[1] 陈希颖[1] 刘雯蓓[1] 常小丽[1] 何彩凤[1] 季必华[1] Wang J un Chen Xi yin Liu Wenbei Chang Xiaoli He Caifeng Ji Bihua(Department of Dermatology ,Yijishan Hospital of Wannan Medical College , Wuhu ,Anhui 241000 ,China)

机构地区：[1]皖南医学院弋矶山医院皮肤性病科,安徽芜湖241000

出　　处：《重庆医学》2017年第13期1773-1774,1778,共3页Chongqing medicine

基　　金：2013年度高校省级自然科学研究项目(KJ2013B324)

摘　　要：目的研究血小板源性生长因子B(PDGF-B)及其受体α(PDGFR-α)mRNA在复发性尖锐湿疣皮损中的表达及意义。方法采用实时荧光定量聚合酶链反应检测复发性、未复发性尖锐湿疣皮损和正常皮肤中PDGF-B及PDGFR-αmRNA表达水平。结果尖锐湿疣复发组、未复发组的PDGF-B和PDGFR-αmRNA表达水平均明显高于对照组,差异有统计学意义(P<0.05);复发组PDGF-B和PDGFR-αmRNA表达水平高于未复发组,复发组治疗前PDGF-B和PDGFR-αmRNA水平高于治疗后(P<0.01)。结论 PDGF-B和PDGFR-αmRNA可能与尖锐湿疣的复发有一定的关系。Objective To investigate the expression of platelet-derived growth factor B（PDGF-B） and PDGFR-α mRNA in the skin lesion of recurrent condyloma acuminatum（CA） and to explore its relationship with recurrent condyloma acuminatum. Methods The expressions of PDGF-B and PDGFR-α mRNA in the lesions of recurrent CA and Nonrecurrent CA were investigated by Real-Time-PCR,and the normal foreskins were taken as controls. Results The PDGF-B and PDGFR-α mRNA levels in the re- current CA group and non-recurrent CA group were significantly higher than those in the normal control group,the differences were statistically significant（P〈0. 05）. The expressions of PDGF-B and PDGFR-α mRNA in the recurrent CA group were higher than those in the non-recurrent CA group（P〈0. 01）. Furthermore,the expressions of PDGF-B and PDGFR-α mRNA before treatment in the recurrent CA group were higher than those after treatment（P〈0.01）. Conclusion PDGF-B and PDGFR-α mRNA might haue a certain relation with CA recurrence.

关 键 词：尖锐湿疣 生长因子 血小板源性 受体 实时荧光定量聚合酶链反应 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]