黄酮类化合物单胺氧化酶抑制作用研究进展  

Research Progress on Flavonoids as Monoamine Inhibitors

作　　者：杨扬[1] 程慧洁 阮班锋[2] YANG Yang CHENG Hui-jie RUAN Ban-feng(Anhui Reserach Institute of Chemical Industry, Hefei 230041, China College of Biological and Pharmaceutical Engineering, Hefei University of Technology, Hefei 230009, China)

机构地区：[1]安徽省化工研究院,安徽合肥230041 [2]合肥工业大学生物与医学工程学院,安徽合肥230009

出　　处：《安徽化工》2017年第2期7-12,共6页Anhui Chemical Industry

摘　　要：黄酮类化合物是一类广泛分布于自然界的天然化合物,具有抗肿瘤、抗氧化、抗炎、血管舒张、神经元保护、保肝等多种生理活性,尤其是具有低毒的优势。研究表明,单胺氧化酶抑制剂可用于治疗神经退行性疾病。总结了近几年类黄酮化合物作为单胺氧化酶抑制剂的研究进展,期望为神经退行性疾病治疗提供参考。Flavonoids are a large class of compounds widely distributed in nature. Many of them express a wide range of biological activities such as anti - tumor, antioxidant, anti - inflammatory, vasodilator, neuron protection, hepatoprotective, and so on, espcially they show so low toxicity. Monoamine oxidase inhibitors have been shown to be useful in the treatment of neurodegenerative diseases. Herein, current researches in flavonoids as monoamine oxidase inhibitors were systematically smnmarized, which can serve as a reference for reatment of neurodegenerative disease.

关 键 词：黄酮类化合物 单胺氧化酶 抑制剂 阿尔茨海默症 帕金森病 

分 类 号：R285[医药卫生—中药学]