α-干扰素雾化吸入联合利巴韦林喷雾剂对小儿疱疹性咽峡炎的影响研究  

Impact on Immune Globulin of α-Interferon Injection in Combination with Ribavirin Aerosol Inhalation on Children with Herpangina

作　　者：任荣 黄旭[2] 

机构地区：[1]铜陵市立医院,安徽铜陵244000 [2]蚌埠医学院第二附属医院,安徽蚌埠233000

出　　处：《北华大学学报（自然科学版）》2017年第3期375-378,共4页Journal of Beihua University（Natural Science）

基　　金：安徽省科技攻关计划项目(1301042221)

摘　　要：目的探讨α-干扰素雾化吸入联合利巴韦林喷雾剂对小儿疱疹性咽峡炎的影响.方法选取60例疱疹性咽峡炎患儿,随机分为研究组和对照组,对照组给予利巴韦林喷雾剂,研究组在使用利巴韦林喷雾剂的基础上给予α-干扰素注射液进行治疗.结果研究组总有效率与对照组相比明显升高(P<0.05).与对照组相比,研究组患儿退热时间、疱疹消退时间及流涎消失时间均明显缩短(P<0.01).经统计分析显示:热退时间、流涎消失时间和疱疹消失时间与开始治疗时间具有正相关性(P<0.05),与单核细胞百分比呈负相关性(P<0.05),与白细胞计数、C-反应蛋白及血红蛋白水平不具有相关性(P>0.05).治疗后,两组患儿的Ig G,Ig A,Ig M水平较治疗前均明显升高(P<0.01),且研究组升高更为明显(P<0.01,P<0.05).两组均未见明显不良反应,安全性好.结论α-干扰素联合利巴韦林治疗小儿疱疹性咽峡炎临床疗效较好,可明显改善患儿的退热、流涎消失及疱疹消退时间,提高免疫蛋白水平,且不增加不良反应,具有临床应用价值.Objective To discuss impact on immune globulin ribavirin aerosol inhalation on children with herpangina. Method of α-interferon injection in combination with 60 cases of children with herpangina were selected, and randomly divided into study group and control group. Patients in the control group were treated with ribavirin spray and those in the study group were treated with a-interferon injection on the basis of ribavirin spray. Results The total effective rate of the study group was significantly higher than that of the control group （P〈0.05）. Compared with those in the control group, the defevescence time, blebsubsidise time and salivation disappearing time were significantly reduced in the study group （P〈0.01） ,which were positively correlated withthe treatment time （ P〈0.05 ）, but negatively with the percentage of monocytes （ P〈0.05 ）, not with the white blood cell count, Creactive protein and hemoglobin level （P〉0.05）. After treatment, IgG, IgA and IgM levels in two groups were significantly increased compared with those before treatment （P〈0.01）, and those in the study group were increased more significantly than those in the control group （P〈0.01 ,P〈0.05）. No significant adverse reactions were found in the two groups, indicating that the safety of this therapy was good. Conclusion The combination of α-interferon with ribavirin may have a better clinical effect on children herpangina, and can obviously improve the children＇ s fever, salivation disappearing time and blebsubsidise time, elevate immunoprotein levels, and should not induce severe adverse reactions, showing a clinical application value.

关 键 词：Α-干扰素 利巴韦林 小儿 疱疹性咽峡炎 免疫球蛋白 

分 类 号：R766.13[医药卫生—耳鼻咽喉科]