山牡荆提取物对大鼠慢性肾炎模型的药效学实验研究  

The Pharmacodynamic Study of Extract of Vitex Quinata on Rat Model of Chronic Glomerulonephritis

作　　者：王飞娟[1] 景鹏 王燕[1] 张爽[1] 高洁[1] 

机构地区：[1]陕西国际商贸学院医药学院,陕西咸阳712046 [2]咸阳市中心医院,陕西咸阳712000

出　　处：《中医药导报》2017年第8期28-30,37,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：陕西国际商贸学院科学研究项目(编号:SMXY201404);陕西省大学生创新创业训练计划项目

摘　　要：目的:探讨山牡荆提取物对大鼠慢性肾炎模型的干预效应。方法:采用煎煮法提取山牡荆,采用喷雾干燥法制备山牡荆提取物粉末;将60只大鼠按体质量随机分为4组,分别为模型组,阳性对照组,山牡荆提取物治疗组,空白对照组,每组15只。前3组建立大鼠慢性肾炎模型,给予相应的药物治疗,剂量为10 g/kg/d,持续4周,空白对照组大鼠注射一定量的蒸馏水。观察山牡荆提取物对模型大鼠相应指标的影响。结果:山牡荆提取物对慢性肾炎模型大鼠尿蛋白、血清肌酐、尿素氮、血脂水平均有明显的改善作用。结论:山牡荆提取物具有治疗大鼠慢性肾炎的功效。Objective： To investigate the therapeutic effect of extract of Vitex quinata on rat model of chronic glomerulonephritis. Methods： The 60 rats were randomly divided into four groups, referred to as moun- tain vitex extract treatment group, positive control group, model group and normal control group, each 15 rats. Forward three groups rat model of chronic glomerulonephritis, given the appropriate medication at a dose of 10 mg/kg/d, for 4 weeks. Results： The corresponding index, urine protein, serum creatinine, blood urea nitrogen, serum lipid levels of rat model significantly improved with extract of Vitex quinata. Conclusion： Extract of Vitex quinata has a therapeutic effect in rats with chronic nephritis.

关 键 词：山牡荆提取物 大鼠 慢性肾炎 

分 类 号：R285.5[医药卫生—中药学]