沙美特罗联合喘可治注射液对COPD伴全身炎症反应患者血清降钙素原与γ干扰素水平影响研究  

Effects of salmeterol combined with Chuankezhi injection on the levels of serum procalcitonin and interferon-γ in COPD patients with systemic inflammatory response

作　　者：吴锋杰[1] 汪晔 

机构地区：[1]浙江省嘉兴市第二医院呼吸科,浙江嘉兴314001 [2]浙江省德清县人民医院呼吸科,浙江德清313200

出　　处：《中国现代医生》2017年第9期9-13,共5页China Modern Doctor

基　　金：浙江省医药卫生科技计划(2015KYA214)

摘　　要：目的探讨沙美特罗联合喘可治注射液对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)伴全身炎症反应患者血清降钙素原与γ干扰素水平的影响。方法选择我院呼吸内科自2015年4月~2016年11月符合条件的COPD伴全身炎症反应患者94例,随机分为对照组47例和治疗组47例,对照组予抗炎、化痰、舒张平滑肌治疗;治疗组在此基础上予沙美特罗联合喘可治注射液治疗,两组共治疗1周为1个疗程,治疗前后采血测定血清白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、γ-干扰素(Interferon-γ,IFN-γ)、降钙素原(procalcitonin,PCT)以及免疫功能,测定肺功能指标,同时对比临床疗效和不良反应状况。结果与治疗前比较,两组治疗后FEV_1、FVC、FEV_1%pre、FEV_1/FVC升高,血清IL-6、TNF-α、IFN-γ、PCT含量降低,血清CD3^+、CD4^+、CD4^+/CD8^+升高,CD8^+降低(P<0.05);与对照组比较,治疗组治疗后FEV_1、FVC、FEV_1%pre、FEV_1/FVC较高,血清IL-6、TNF-α、IFN-γ、PCT含量较低,血清CD3^+、CD4^+、CD4^+/CD8^+较高,CD8^+较低(P<0.05);对照组有效率为74.47%(35/47),治疗组有效率为91.49%(43/47),治疗组高于对照组(P<0.05);两组间不良反应发生率比较,差异无统计学意义(P>0.05)。结论沙美特罗联合喘可治注射液对COPD伴全身炎症反应患者疗效确切,降低炎症指标,提高免疫功能,值得临床广泛推广。Objective To investigate the effect of salmeterol combined with Chuankezhi injection on the levels of serum procalcitonin and interferon-γin patients with chronic obstructive pulmonary disease（COPD） complicated with systemic inflammatory response. Methods A total of 94 patients with COPD and systemic inflammatory response in the Department of Respiratory Medicine from April 2015 to November 2016 who met the criteria were chosen and randomly di vided into control group（n=47） and treatment group（n=47）. The control group was given anti-inflammatory, phlegm and muscle relaxation treatment. The treatment group was treated with salmeterol combined with＇ Chuankezhi injection on the basis of the treatment of the control group. The two groups were treated for 1 week for a course of treatment. The blood was collected before and after treatment to detect serum interleukin-6 （IL-6）, tumor necrosis factor-o~ （TNF-ot）, interferon-γ （IFN-γ）, procalcitonin （PCT） and immune function, and the pulmonary function index was determined. Meanwhile, the clinical efficacy and complications between the two groups were compared. Results FEVI, FVC, FEV1% pre, FEVγFVC in the two groups after treatment were higher than those before treatment, and the levels of serum IL-6, TNF-α, IFN-γ and PCT in the two groups after treatment were lower than those before treatment. CD3^＋, CD4^＋ and CD4＋/CD8＋ in the two groups after treatment were higher than those before treatment and CD8^＋ in the two groups after treatment was lower than that before treatment（P〈O.05）. FEV, FVC, FEVl%pre and FEV~/FVC in the treatment group after treatment were higher than those in the control group. And the serum IL-6, TNF-α, IFN-γ and PCT in the treatment group were lower than those in the control group. CD3^＋, CD4^＋ and CD4^＋/CD8＋ in the treatment group after treatment were higher than those in the control group and CD8^＋ in treatment group after treatment was lower than that in the control group （P〈0.05）

关 键 词：沙美特罗 喘可治注射液 COPD 全身炎症反应 降钙素原 Γ干扰素 

分 类 号：R563.9[医药卫生—呼吸系统]