Ghrelin如何参与骨代谢:理论研究的最新进展与现状  

Ghrelin participates in bone metabolism:the newest research progress

作　　者：陈宏 毕然然[2] 陈良 竺琼 

机构地区：[1]上海市徐汇区凌云社区卫生服务中心,上海市200237 [2]同济大学附属杨浦医院,上海市200090

出　　处：《中国组织工程研究》2017年第12期1940-1945,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:Ghrelin是最近在人及大鼠胃部发现的一种脑肠肽。作为促生长激素分泌物受体的内源性配体,Ghrelin能强烈刺激生长激素的释放。尽管促生长激素分泌素受体在众多外周组织中有表达,但是很少有人知道关于Ghrelin对骨代谢的影响以及促生长激素分泌素受体在骨组织中的表达。目的:对Ghrelin参与骨代谢的研究进展进行综述。方法:第一作者以"Ghrelin,骨代谢"检索CNKI数据库、万方数据库,以"Ghrelin,Bone metabolism"检索Pub Med数据库、Springerlink数据库。纳入有关Ghrelin以及参与骨代谢的研究,排除重复研究。通过阅读摘要初步筛选,共选取53篇文献进行分析。结果与结论:Ghrelin是在小鼠和人的胃内分泌细胞及下丘脑弓状核发现的一种含有28个氨基酸残基的多肽,其对消化系统、神经系统、免疫系统以及内分泌系统影响较大,同时,Ghrelin在激素分泌、糖代谢、免疫、细胞增殖、炎症等许多方面均有作用。血Ghrelin对骨的生长、发育具有一定影响,对成骨细胞的影响主要表现为促进其增殖分化,抑制其凋亡。通过减少Runx2蛋白的表达量抑制C3H10T1/2细胞早期成骨分化,并能通过降低PPARγ2的表达而减弱成脂分化,促进成骨分化。但促生长激素分泌素受体在骨组织中的表达研究报道较少。BACKGROUND：Ghrelin is a newly discovered brain-gut peptide from the stomach of human and rats. As an endogenous ligand for growth hormone secretagogue receptor （GHSR）, ghrelin can notably stimulate the release of growth hormone. Although GHSR is expressed in many peripheral tissues, little is known about the influence of ghrelin on bone metabolism and GHSR expression in bone tissue. OBJECTIVE：To review the research progress of ghrelin in bone metabolism.METHODS：The first author retrieved CNKI, WanFang, PubMed, and Springerlink databases with the keywords of＂Ghrelin, bone metabolism＂in Chinese and English, respectively. The studies regarding ghrelin and its involvement in bone metabolism were included, and repetitive ones were excluded. A total of 53 eligible literatures were selected through skimming abstracts. RESULTS AND CONCLUSION：Ghrelin is a peptide composed of 28 amino acids discovered in gastric endocrine cells and hypothalamic arcuate nucleus in mice and human, which makes a great effect on digestive, nervous, immune and endocrine systems, and also plays a role in hormone secretion, glucose metabolism, immunity, cell proliferation, and inflammation. Serum ghrelin makes a certain influence on bone growth and development, and promotes the differentiation and proliferation of osteoblasts, and inhibits its apoptosis. Additionally, ghrelin suppresses the early osteogenic differentiation of C3H10T1/2 cells by upregulating the expression of Runx2 protein, and attenuates adipogenic differentiation by downregulating PPARγ2 expression, thus inducing osteogenic differentiation. However, few studies have addressed the expression of GHSR in bone tissue.

关 键 词：组织构建 骨组织工程 骨代谢 促生长激素分泌素受体 

分 类 号：R318[医药卫生—生物医学工程]