阿托伐他汀辅助治疗对原发性高血压患者血清炎症因子水平的影响及疗效观察  

Effect and efficacy of atorvastatin adjuvant therapy on serum inflammatory factors for essentital hypertension

作　　者：郑继平[1] 

机构地区：[1]浙江省台州市第一人民医院心内科,浙江台州318020

出　　处：《中国现代医生》2017年第11期33-35,共3页China Modern Doctor

摘　　要：目的探讨阿托伐他汀辅助治疗原发性高血压(EH)的疗效及对血清炎症因子水平的影响。方法将84例正常血脂EH患者患者随机分为观察组与对照组。两组均予以相同的药物控制血压(硝苯地平控释片口服30 mg/次,1次/d,口服)。观察组在此基础上加用阿托伐他汀20 mg/次,1次/d,口服,连用8周。观察并判断两组治疗前与治疗8周后血清超敏C反应蛋白(hs-CRP)、白介素-10(IL-10)和肿瘤坏死因子-α(TNF-α)水平的变化,并比较降压效果及不良反应。结果治疗8周后,两组血清hs-CRP和TNF-α水平明显下降,IL-10水平明显上升(P<0.05或P<0.01),且观察组变化幅度更明显(P<0.05);同时观察组的降压效果明显优于对照组(χ~2=4.09,P<0.05);两组出现不良反应8例,其中对照组3例和观察组5例,症状均较轻,两组比较差异不明显(χ~2=0.14,P>0.05)。结论阿托伐他汀辅助治疗正常血脂EH患者的降压效果较确切,其作用机制可能与其能明显降低血清hs-CRP和TNF-α水平,升高血清IL-10水平及有效抑制血管壁慢性炎症反应密切相关。Objective To investigate the effect and efficacy of atorvastatin adjuvant therapy on serum inflammatory cytokines for essential hypertension（EH）. Methods 84 EH patients with normal blood lipid were randomly divided into observation group and control group. Both groups were given the same drug for the control of blood pressure （nifedipine controlled-release tablets 30 mg/time, once a day, oral administration）. On the basis of the control group, the observation group was further given atorvastatin 20 mg/time, once a day, oral administration for 8 weeks. Changes of serum high sensitivity C-reactive protein （hs-CRP）, interleukin-10 （IL-10） and tumor necrosis factor-α （TNF-α in the two groups before the treatment and 8 weeks after the treatment were observed and evaluated. The antihypertensive effect and adverse reactions were compared. Results After 8 weeks of treatment, the levels of serum hs-CRP and TNF-α were significantly decreased and the level of IL-10 was significandy increased （P〈0.05 or P〈0.01）, and the changes in the observation group were more obvious（P〈0.05）; at the same time, the antihypertensive effect in the observation group was significantly better than that in the control group（Х^2=4.09, P〈0.05）. There were 8 adverse reactions in the two groups, including 3 cases in the control group and 5 cases in the observation group. The differences in symptoms were mild, were not significant between the two groups（Х^2=0.14, P〉0.05）. Conclusion Atorvastatin adjuvant therapy has an exact antihypertensive effect in the EH patients with normal blood lipid. Its mechanism may be closely related to its ability to significantly reduce the levels of serum hs-CRP and TNF-α, increase the level of serum IL-10, and effectively inhibit the chronic inflammation of vascular wall.

关 键 词：原发性高血压 阿托伐他汀 超敏C反应蛋白 白介素-10 肿瘤坏死因子-Α 

分 类 号：R544.1[医药卫生—心血管疾病]