胸腰段血管瘤有限元模型建立及生物力学分析  

Finite element model establishment of thoracolumbar hemangioma and biomechanical analysis

作　　者：江仁兵[1] 董磊[1] 刘启震 武峻申 白靖平[1] 

机构地区：[1]新疆医科大学附属肿瘤医院骨与软组织病区

出　　处：《中国组织工程研究》2017年第11期1753-1757,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(81360282)~~

摘　　要：背景:关于胸椎段肿瘤生物力学方面的研究比较多,但是有关有限元分析胸腰段椎体血管瘤骨折风险的研究不多。目的:建立胸腰段椎体血管瘤有限元模型,分析其生物力学分布特点,评估脊椎血管瘤的骨折风险。方法:建立T_(12)-L_2椎体的正常椎体、血管瘤椎体(血管瘤占椎体松质骨比例分别为20%,40%,60%,80%)、骨水泥填充椎体三维有限元模型,并进行力学分析。分别予以600 N垂直静态压力下正常椎体、血管瘤椎体、骨水泥填充的椎体等效应力分布及特点。结果与结论:(1)建立了有效的T_(12)-L_2椎体有限元模型。在静态压力作用下3组模型L_1椎体皮质骨应力传导无明显差异,应力最大部均出现在椎弓根基底部、关节突关节及峡部;(2)在骨皮质完整情况下,椎体血管瘤占椎体松质骨20%-40%时病变椎体与正常椎体应力分布无统计学差异;当比例为60%-80%时,病变椎体与正常椎体应力分布有统计学差异;(3)建立的胸腰段三维有限元模型具有可用性;生物力学实验显示,椎体皮质骨完整性、松质骨破坏比例是椎体血管瘤骨折风险关键因素。BACKGROUND： Most of studies focus on the biomechanical characteristics of thoracic spine neoplasm, but there is little report on the fracture risk in the patients with vertebral hemangioma through finite element analysis.OBJECTIVE： To establish a finite element model of vertebral hemangioma, and to analyze its biomechanical characteristics, and assess the risk of vertebral fracture.METHODS： Three-dimensional finite element models of T12-L2 vertebrae from normal individuals, the patients with vertebral hemangioma （hemangioma accounting for 20%, 40%, 60%, 80% of the vertebral cancellous bone） and bone cement filling were established, respectively, and then the mechanical characteristics were analyzed. The stress distribution and characters of each model were determined under a vertical static pressure of 600 N.RESULTS AND CONCLUSION： （1） Three-dimensional finite element models of T12-L2 vertebrae were established successfully. Under static pressure, the stress distribution of L1 cortical bone showed no significant difference among models, and the maximum stress all occurred at the base of pedicle, zygapophysial joint and isthmus. （2） The stress distribution did not differ significantly between vertebral hemangioma accounting for 20%-40% of vertebral cancellous bone with complete cortical bone and normal ones, but which differed significantly in hemangioma accounting for 60%-80%. （3） To conclude, the established thoracolumbar three-dimensional model is available. Additionally,biomechanical tests manifest that the completeness of cortical bone and destruction ratio of cancellous bone destruction are key factors for the fracture risk of vertebral hemangioma.

关 键 词：骨科植入物 脊柱植入物 有限元 椎体血管瘤 等效应力 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]