TCF7L2基因rs7903146、rs12255372多态性与妊娠期糖尿病的Meta分析  

Meta-analysis on the polymorphism of rs7903146 and rs12255372 in TCF7L2 gene and gestational diabetes mellitus

作　　者：张晓宇[1] 方正美 段滢[1] 梁伟[1] 朱丽君[1] 常微微[1] 姚应水[1] 

机构地区：[1]皖南医学院公共卫生学院,安徽芜湖241002

出　　处：《皖南医学院学报》2017年第2期170-174,共5页Journal of Wannan Medical College

基　　金：国家自然科学基金项目(81441127)

摘　　要：目的:系统评价TCF7L2基因rs7903146、rs12255372多态性与妊娠期糖尿病(GDM)的关系。方法:通过Pub Med数据库、Wiley数据库、Elsevier数据库、中国生物医学文献数据库、万方数据库、重庆维普网、中国知网数据库查全关于TCF7L2基因rs7903146、rs12255372与GDM的研究,采用State11.0软件对纳入的文献进行Meta分析。结果:共纳入13篇关于rs7903146与GDM的研究。Meta分析结果显示rs7903146(TT+TC)/CC:OR=1.642,95%CI:1.493~1.806,P<0.001;T/C:OR=1.498,95%CI:1.392~1.612,P<0.001,且亚组分析欧洲、亚洲人群中差异有统计学意义,美洲人群中差异无统计学意义。关于rs12255372研究共纳入7篇与GDM的研究。Meta分析结果显示rs12255372(TT+TG)/GG:OR=1.569,95%CI:1.108~2.222,P=0.011;T/G:OR=1.491,95%CI:1.144~1.942,P=0.003。结论:TCF7L2基因rs7903146 TT+CT基因型、rs12255372 TT+GT基因型是GDM患者发病的危险因素;rs7903146等位基因T以及rs12255372等位基因T均是GDM患者发病的危险因素。Objective：To systematically review the relationship between polymorphism of rs7903146 and rs12255372 inTCF7L2 gene and gestational diabetes mellitus（GDM）.Methods：Publications on the polymorphism of rs7903146 and rs12255372 inTCF7L2 gene and GDM were retrieved from PUBMED database,Wiley database,Elsevier database,Chinese Biomedical Literature Database,Wanfang database,Chongqing VIP network and CNKI database,and the data extracted from the literatures included were heterogeneously tested using software Stata（version 11.0）.Results：Thirteen studies on the CTF7L2 gene rs7903146 polymorphism were finally included.Meta-analysis indicated that rs7903146 polymorphism was associated with TT＋TC/CC（OR =1.642,95%CI：1.493-1.806,P〈0.001） and T/C（OR =1.498,95%CI：1.392-1.612,P〈0.001）.The difference was significant in European and Asian population by subgroup analysis results,yet was not significant in American population.Final inclusion of 7 studies on rs12255372 polymorphism through meta-analysis showed that rs12255372 polymorphism was associated with TT＋TG/GG（OR =1.569,95%CI：1.108-2.222,P=0.011） and T/G（OR =1.491,95%CI：1.144-1.942,P=0.003）.Conclusion： The findings suggest that population with TCF7L2 rs7903146 and rs12255372 gene polymorphism（TT＋CT and TT＋GT gene-type）may be susceptible to GDM,and allelic gene T at rs7903146 and rs12255372 is also the risk factor for GDM.

关 键 词：妊娠期糖尿病 TCF7L2基因 基因多态性 META分析 

分 类 号：R714.256[医药卫生—妇产科学]