乳腺腺样囊性癌临床病理特点  

Clinicopathological characteristics of adenoid cystic carcinoma of the breast： an analysis of 3 cases

作　　者：袁静萍[1] 阎红琳 吴昊[1] 高利昆[1] 饶洁[1] 胡继昌[1] 袁修学[2] 

机构地区：[1]武汉大学人民医院病理科,430060 [2]武汉科技大学基础医学院,430065

出　　处：《中华内分泌外科杂志》2017年第2期107-109,126,共4页Chinese Journal of Endocrine Surgery

基　　金：湖北省自然科学基金课题（2013CFB374）

摘　　要：目的探讨乳腺腺样囊性癌的临床病理特征及鉴别诊断。方法收集3例乳腺腺样囊性癌的临床病理资料并随访，观察其临床病理特征和免疫表型。结果3例均为女性，平均年龄61（55~72）岁。肿块均位于乳晕旁，大体边界清楚，切面呈灰白色。肿瘤在结构上由肌上皮和腺上皮2种细胞构成筛孔型、管状小梁状型2种类型，免疫组织化学显示肌上皮细胞表达SMA、CK5/6、P63、CD117，腺上皮表达CK18、EMA、CK7。2种细胞均不表达ER、PR、HER2、CD10。结论乳腺腺样囊性癌是一种少见的乳腺肿瘤，是基底细胞亚型，但具有良好的预后。其特征性的组织形态、免疫组化表型有助于诊断和鉴别诊断。ObjectiveTo explore the clinicopathological features and diagnosis of adenoid cystic carcinoma of the breast （ACCB） .MethodsClinical data of 3 cases of ACCB were collected and followed up to observe the clinical pathological features. Immunohistochemistry was used to determine the immune phenotype.ResultsAll the 3 cases were female, aging from 55 to 72 years old （61 years old as the average） . The tumors were found in subareolar region well-circumscribed. ACCB was characterized by the presence of a dual cell population of luminal and basaloid cells arranged in cribriform and tubular-trabecular patterns. On immunohistochemical staining, the myoepithelial cells expressed SMA, CK5/6, P63, CD117 and the glandular epithelium cells were mostly positive for CK18, EMA, CK7, while no expression of ER, PR, HER-2, CD10 was observed.ConclusionsACCB is a rare neoplasm with a triple-negative, basal-like phenotype, but exhibits an indolent clinical behavior. The diagnosis can be worked out by evaluation of clinical characterstics, histological and immunohistochemical features.

关 键 词：乳腺 腺样囊性癌 临床病理学 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]