白芍总苷防治放射性肝损伤形成的临床研究及其作用机制  

Clinical efficacy and mechanism of total glucosides from white paeony for radioactive liver damage

作　　者：高世乐[1] 胡宗涛[1] 董六一[2] 费振乐[3] 马金柯 刘纪云[3] 

机构地区：[1]中国人民解放军第105医院肿瘤三科,安徽合肥230031 [2]安徽医科大学药理学教研室,安徽合肥230032 [3]中国人民解放军第105医院放疗科,安徽合肥230031

出　　处：《中国中药杂志》2017年第7期1390-1394,共5页China Journal of Chinese Materia Medica

基　　金：解放军第105医院院管课题(10YG12)

摘　　要：探讨白芍总苷防治放射性肝损伤的作用,并探讨其可能作用机制。选择解放军第105医院三维适形放射治疗原发性肝癌患者36例,随机分为单纯照射组、白芍总苷组、对照组。ELISA法检测各组血清中AST,ALT,HA,LN,PCⅢ,CIV,TGF-β_1含量。与单纯照射组及对照组相比,白芍总苷能明显降低血清AST,ALT,HA,LN,PCⅢ,CIV,TGF-β_1含量(P<0.05或P<0.01)。研究得出白芍总苷可有效防治放射性肝损伤,其作用机制可能与抑制TGF-β_1表达,减少胶原纤维合成有关。To discuss the effects of total glucosides from white paeony on preventing and treating radioactive liver damage, and explore its possible mechanisms. Thirty-six patients with primary hepatic carcinoma from 105th Hospital of Chinese PLA were treated with 3-dimensional conformal radiotherapy and randomly divided into simple irradiation group, total glucosides from white paeony group, and control group. The levels of AST, ALT, HA, LN, PCⅢ, CIV and TGF-β1 in serum of various groups were determined by using ELISA method. As compared with the simple irradiation group and control group, total glucosides from white paeony could obviously decrease the levels of AST, ALT, HA, LN, PCⅢ, CIV and TGF-β1（P〈0.05, P〈0.01）. The results showed that the total glucosides from white paeony could effectively prevent and treat radioactive liver damage, and its mechanism might be associated with decreasing the levels of TGF-β1, and inhibiting the synthesis of collagen synthesis.

关 键 词：白芍总苷 小柴胡汤 放射性肝损伤 TGF-Β1 作用机制 

分 类 号：R285.6[医药卫生—中药学]