硫酸头孢匹罗与奥硝唑配伍稳定性考察  

Investigation of the Compatible Stability of Cefpirome Sulfate with Ornidazole

作　　者：李红[1] 邹琼[1] 平政[1] 魏丽[1] 常玉梅[1] 杨继章[2] 

机构地区：[1]解放军第252医院药品配送保障中心,河北保定071000 [2]河北医科大学第一医院药剂科,石家庄050031

出　　处：《中国药房》2017年第13期1784-1786,共3页China Pharmacy

摘　　要：目的:考察硫酸头孢匹罗与奥硝唑的配伍稳定性。方法:在室温[(20±1)Ⅳ]下,观察注射用硫酸头孢匹罗与注射用奥硝唑在0.9%氯化钠注射液和5%葡萄糖注射液中配伍0、1、2、4、6 h后的外观(颜色、澄清度、沉淀与气体)、p H值变化,采用反相高效液相色谱法测定两药配伍后的含量变化。结果:两药配伍后6 h内外观无明显变化,p H值在3.359~3.588之间;与配伍初时(0 h)比较,各时间点硫酸头孢匹罗、奥硝唑在0.9%氯化钠注射液中的含量在100.2%~100.3%、99.9%~100.4%之间,在5%葡萄糖注射液中的含量在99.7%~99.9%、99.4%~99.6%之间。结论:室温条件下,6 h内硫酸头孢匹罗与奥硝唑在0.9%氯化钠注射液和5%葡萄糖注射液中配伍后的外观、p H值与含量稳定。OBJECTIVE：To investigate the compatible stability of cefpirome sulfate with ornidazole. METHODS：At room temperature [（20±1）℃],the appearances（color,clarity,sedimentation and gas）and pH changes of the mixtures by Cefpirome sulfate for injection with Ornidazole for injection in 0.9% Sodium chloride injection and 5% Glucose injection after 0,1,2,4,6 h were observed. RP-HPLC was adopted to determine its content changes. RESULTS：No significant change was noted for the mix-ture in appearance within 6 h,pH value ranged in 3.359-3.588;compared with the beginning（0 h）,the contents of cefpirome sul-fate and ornidazole ranged in 100.2%-100.3%,99.9%-100.4% in 0.9% Sodium chloride injection at each time point,as well as 99.7%-99.9%,99.4%-99.6%in 5%Glucose injection. CONCLUSIONS：At room temperature,cefpirome sulfate mixed with orni-dazole show stable appearance,pH value and content in 0.9%Sodium chloride injection and 5%Glucose injection within 6 h.

关 键 词：硫酸头孢匹罗 奥硝唑 配伍 稳定性 外观 PH值 含量 

分 类 号：R978.1[医药卫生—药品] R969.2[医药卫生—药学]