A型肉毒毒素注射联合乳头内陷矫正器治疗重度乳头内陷的疗效  

Combination of BTX-A and nipple retractor in correcting severe inverted nipple

作　　者：龙笑[1] 白明[1] 俞楠泽[1] 黄久佐[1] 赵茹[1] 王晓军[1] 

机构地区：[1]北京协和医院整形外科,100730

出　　处：《中华医学美学美容杂志》2017年第2期73-75,共3页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的 探讨A型肉毒毒素注射联合乳头内陷矫正器治疗重度乳头内陷的疗效.方法 将20例诊断为双侧重度乳头内陷患者,分为单独应用乳头内陷矫正器组和A型肉毒毒素注射联合乳头内陷矫正器组,每组10例.所有患者在矫正器去除后1个月、3个月、6个月进行随访,根据治疗前、治疗后侧位像测量乳头凸度变化,比较两组有效率及并发症发生情况.结果 A型肉毒毒索注射联合乳头内陷矫正器组在矫正器去除后1个月、3个月及6个月的平均乳头凸度为（1.12±0.13）,（0.95±0.10）及（0.73±0.11） cm,与单独应用矫正器组（0.81±0.10）,（0.72±0.12） cm和（0.53±0.10） cm比较,两组差异有统计学意义（P＜0.05）.A型肉毒毒素注射联合乳头内陷矫正器组并发症发生（皮肤糜烂0例、色素脱失1例、钢丝移位0例）少于单独应用矫正器组（皮肤糜烂2例、色素脱失1例、钢丝移位1例）.两组患者均无乳头坏死等严重并发症发生.结论 应用A型肉毒毒素注射联合乳头内陷矫正器可有效治疗重度乳头内陷,并发症发生率较低,且矫正效果优于单独应用乳头内陷矫正器.Objective To investigate the clinical effect of type A botulinum toxin and nipple retractor in correcting severe inverted nipples.Methods All the patients with bilateral severe inverted nipples that sought consulting in the Plastic and Reconstructive Surgery Center of Peking Union Medical College Hospital were included in this study and the patients were randomized into different treatment group with nipple retractor only or BTX-A （Lanzhou,China） combined with nipple retractor.In the combined therapy group,50 u BTX-A was injected into the bottom of each nipple.2 weeks later,nipple retractor was placed and kept wearing for 6 months.For the retractor only group,no BTX-A was used.All the patients were followed up at 1 month,3 months and 6 months after the operation.Nipple projection was measured according to the profile view of pre-and post-operation.Effectiveness and complication rate were compared between the two groups.Results 20 patients were included in this study.Average nipple projection in the combined therapy group was （1.12±0.13） cm,（0.95± 0.10） cm and （0.73±0.11） cm （3 months,6 months and 12 months post-operation,respectively）,which had a significant difference from that of the retractor group [（0.81±0.10） cm,（0.72±0.12） cm and （0.53±0.10） cm].Total complication rate of combined group was also lower than that of retractor group.The complications of the combined therapy group included hypopigmentation （1 case）,without skin ulcer or wire dislocation.However in the retractor group,complications included skin ulcer （2 cases）,hypopigmentation （1 case） and dislocation （1 case）.No severe complications such as nipple necrosis happened in both groups.Conclusions BTX-A combined with nipple retractor is an effective method in correcting severe inverted nipple with low complication rate.

关 键 词：乳头内陷 A型肉毒毒素 矫正器 

分 类 号：R622[医药卫生—整形外科] R655.8[医药卫生—外科学]