自体脂肪颗粒注射与透明质酸注射填充鼻唇沟凹陷的临床效果  

Comparison of clinical effects between autologous fat and hyaluronic acid in filling nasolabial grooves

作　　者：胡晓根[1] 马海欢[1] 曾高[1] 高占巍[1] 路会[1] 黄文罡[1] 任冲[1] 薛志强[1] 齐慧颉[1] 齐彦文[1] 陈波[1] 周洋[1] 

机构地区：[1]中日友好医院整形外科,北京100029

出　　处：《中华医学美学美容杂志》2017年第2期92-94,共3页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的 比较自体脂肪颗粒注射和透明质酸注射填充鼻唇沟凹陷的临床效果.方法 选择60例要求鼻唇沟填充美容就医者,随机分为自体脂肪颗粒注射填充组（30例）和透明质酸注射填充组（30例）,采用治疗前、治疗后面部照相,鼻唇沟评分,比较两种方法治疗后半年、1年的临床效果.结果 两组治疗后半年效果差异无统计学意义（P＞0.05）,治疗后1年效果差异有统计学意义（P＜0.05）.多数美容就医者自体脂肪颗粒注射后早期肿胀、瘀斑等局部反应明显,持续时间较长;透明质酸注射后肿胀及红斑反应较轻,治疗后恢复快,无药物过敏反应.两种治疗方法均未发现严重并发症.结论 自体脂肪颗粒注射和透明质酸注射填充鼻唇沟凹陷,治疗后半年两种方法治疗效果无显著差别,治疗后1年自体脂肪颗粒注射有效率高于透明质酸注射,透明质酸需要补充注射,两种方法均安全、有效,医师可以根据情况选择使用.Objective To compare the efficacy between autologous fat and hyaluronic acid in filling nasolabial grooves.Methods Sixty patients who wanted improvement of nasolabial grooves were involved in the study.They were randomly and equally classified into two groups：autologous fat injection group and hyaluronic acid injection group.Photographs were taken before,half a year,and one year after injection.The nasolabial grooves were also graded before,half a year,and one year after injection.The grade improvement was obtained after postoperative grade minus preoperative grade.If the grade improvement was more than 1 grade,the treatment was regarded as effective to evaluate the outcome between the two methods.Results The results of the two groups were tested by SPSS 13.0 software.The effects of the two methods were not significantly different after half a year of filling （P〉0.05）.The difference was significant one year after filling （P〈0.05）.In autologous fat injection,the patients had a long and magnificant swelling and redness around the nasolabial grooves;on the contrary,the patients who underwent hyaluronic acid had slight and short-time local reaction like swelling and redness.No other serious complications were found in both the groups.Conclusions The effects of the autologous fat and the hyaluronic acid are equal after half a year of filling.The autologous fat has a longer effect in one year.Both methods are safe and effective.Surgeons can select the method accordingly.

关 键 词：脂肪颗粒 自体 透明质酸 鼻唇沟 填充 

分 类 号：R62[医药卫生—整形外科]