芪防鼻敏颗粒抗炎、抗过敏作用研究  

Anti-inflammatory and Anti-allergic Effects of Qifangbimin Particle

作　　者：续艳[1] 楚慧伦 孔德明[1] 丁子桐 高琴琴[1] 阎玥[2] 孙文燕[1] 李友林[2] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]中日友好医院国家中医药管理局肺病慢性咳喘重点研究室

出　　处：《中国药师》2017年第5期816-819,共4页China Pharmacist

基　　金：北京市科学技术委员会"十病十药"研发专项课题(编号:Z141100002214018)

摘　　要：目的:初步探讨中药复方芪防鼻敏颗粒的抗炎、抗过敏作用。方法:采用二甲苯致小鼠耳廓肿胀法和大鼠棉球肉芽组织形成法观察芪防鼻敏颗粒的抗炎作用,采用大鼠同种被动皮肤过敏反应实验和小鼠耳异种被动皮肤过敏反应观察芪防鼻敏感颗粒的抗过敏作用。结果:与空白组比较,芪防鼻敏颗粒各剂量组可显著降低二甲苯所致小鼠耳廓肿胀度(P<0.01或0.05),对大鼠棉球肉芽组织增生无明显抑制作用。与空白组比较,芪防鼻敏颗粒各剂量组可明显降低卵蛋白所致大鼠皮肤蓝斑A值(P<0.01或0.05),芪防鼻敏颗粒高剂量组可显著降低小鼠耳廓蓝染程度(P<0.05)。结论:芪防鼻敏颗粒具有一定抗炎、抗过敏作用。Objective： To research the anti-inflammatory and anti-allergic effects of Qifangbimin particle. Methods： The anti- inflammatory effects were observed by the methods of xylene-induced ear-swelling in mice and cotton-ball induced granuloma in rats. The anti-allergic effects were evaluated by the method of passive skin allergy model in rats and ear-heterogeneous passive skin allergy model in mice. Results： In the treatment groups with Qifangbimin particle, the swelling degree of ear edema induced by dimethylbenzene in mice was significantly suppressed when compared with that in the control groups （P 〈 0.01 or 0.05 ） , however, the particle had no significantly inhibitory effect on granulation tissue hyperplasia induced by cotton-ball in rats. The Qifangbimin particle groups obviously decreased the ahsorbance value of locus coeruleus on rats＇ back （ P 〈 0.01 or 0.05 ）, and Qifangbimin particle at high dose significantly reduced the absorbance value of locus coeruleus of auricle in mice （ P 〈 0.01 or 0.05 ） . Conclusion ： Qifangbimin particle has significant anti-inflammatory and antiallergic effects.

关 键 词：芪防鼻敏颗粒 抗炎 抗过敏 实验研究 

分 类 号：R285.5[医药卫生—中药学]