地榆鞣质提取物对大鼠心、肝、脑及肾组织体外抗脂质过氧化作用的研究  

In vitro Antilipid-peroxidation Effects of Tannins Extract from Sanguisorba Officinalis on Heart,Liver,Brain and Kidney of Rats

作　　者：陈鹏[1] 汪静[1] 张红盼[1] 吴玥[1] 周本宏[1,2] 

机构地区：[1]武汉大学人民医院药学部,武汉430060 [2]武汉大学药学院

出　　处：《中国药师》2017年第5期824-827,共4页China Pharmacist

摘　　要：目的:研究地榆鞣质提取物对大鼠心、肝、脑、肾组织体外抗脂质过氧化作用。方法:采用分光光度法测定地榆鞣质提取物对由Fe^(2+)-半胱氨酸(Fe^(2+)-Cys)体系、Fe^(2+)-维生素C(Fe^(2+)-VitC)体系、Fe^(2+)-过氧化氢(Fe^(2+)-H_2O_2)体系诱导的大鼠心、肝、脑、肾组织体外脂质过氧化的抑制作用。结果:地榆鞣质对Fe^(2+)-Cys、Fe^(2+)-VitC、Fe^(2+)-H_2O_2诱导的大鼠脑、心、肝匀浆、肾及线粒体脂质过氧化产生的MDA的抑制作用显著。结论:地榆鞣质对大鼠心、肝、脑及肾组织体外抗脂质过氧化具有较强保护作用,值得进一步研究与开发。Objective： To study the in vitro antilipid-peroxidation effects of tannins extract from Sanguisorba officinalis on heart, liver, brain and kidney of rats. Methods： The in vitro inhibitory effects of tannins extract from Sanguisorba officinalis on lipid-peroxi- dation of heart, liver, brain and kidney of rats induced by Fe^2＋ -cysteine （Fe^2＋ -Cys）, Fe^2＋ -vitamin C （Fe^2＋ -Vit C） and Fe^2＋ -H2 02 were determined by spectrophotometry. Results： The inhibitory effects of tannins extract from Sanguisorba officinalis on MDA produced by lipid-peroxidation of brain, heart, liver homogenate, kidney and mitochondria of rats induced by Fe^2＋-Cys, Fe^2＋ -Vit C and Fe^2＋ - H2O2 were all significant. Conclusion： Tannins from Sanguisorba officinalis has good in vitro protective effects on antilipid-peroxidation of heart, liver, brain and kidney of rats, which is worth studying further.

关 键 词：地榆 鞣质 脂质过氧化 丙二醛 自由基 

分 类 号：R285.5[医药卫生—中药学]